Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores.
Amino Acids
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemical synthesis
Cell Line, Tumor
Cell Survival
/ drug effects
Chemistry Techniques, Synthetic
Cytotoxins
/ chemical synthesis
Dose-Response Relationship, Drug
HeLa Cells
Humans
Inhibitory Concentration 50
MCF-7 Cells
Molecular Structure
Morpholines
/ chemistry
Piperazines
/ chemistry
Structure-Activity Relationship
Triazoles
/ chemistry
Vinblastine
/ analogs & derivatives
IC50 values
Vinca alkaloids
anticancer drugs
organic synthesis
pharmacophores
vindoline
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
24 Feb 2020
24 Feb 2020
Historique:
received:
04
02
2020
revised:
20
02
2020
accepted:
20
02
2020
entrez:
28
2
2020
pubmed:
28
2
2020
medline:
15
12
2020
Statut:
epublish
Résumé
New
Identifiants
pubmed: 32102414
pii: molecules25041010
doi: 10.3390/molecules25041010
pmc: PMC7070384
pii:
doi:
Substances chimiques
Amino Acids
0
Antineoplastic Agents, Phytogenic
0
Cytotoxins
0
Morpholines
0
Piperazines
0
Triazoles
0
vindoline
571PJ1LW03
Vinblastine
5V9KLZ54CY
morpholine
8B2ZCK305O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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