A pilot multi-centre prospective randomised controlled trial of RECELL for the treatment of venous leg ulcers.
Aged
Aged, 80 and over
Cell Transplantation
/ methods
Compression Bandages
Female
Fibroblasts
/ transplantation
Humans
Keratinocytes
/ transplantation
Male
Melanocytes
/ transplantation
Middle Aged
Patient Satisfaction
Pilot Projects
Prospective Studies
Skin Transplantation
/ methods
Transplantation, Autologous
Treatment Outcome
Varicose Ulcer
/ pathology
Wound Healing
RECELL
autologous skin cell suspension
compression therapy
health-related quality of life
venous leg ulcers
Journal
International wound journal
ISSN: 1742-481X
Titre abrégé: Int Wound J
Pays: England
ID NLM: 101230907
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
16
10
2019
accepted:
06
12
2019
pubmed:
28
2
2020
medline:
7
4
2021
entrez:
28
2
2020
Statut:
ppublish
Résumé
Venous leg ulcers (VLUs) have a significant impact on approximately 3% of the adult population worldwide, with a mean NHS wound care cost of £7600 per VLU over 12 months. The standard care for VLUs is compression therapy, with a significant number of ulcers failing to heal with this treatment, especially with wound size being a risk factor for non-healing. This multicentre, prospective, randomised trial evaluated the safety and effectiveness of autologous skin cell suspension (ASCS) combined with compression therapy compared with standard compression alone (Control) for the treatment of VLUs. Incidence of complete wound closure at 14 weeks, donor site closure, pain, Health-Related Quality of Life (HRQoL), satisfaction, and safety were assessed in 52 patients. At Week 14, VLUs treated with ASCS + compression had a statistically greater decrease in ulcer area compared with the Control (8.94 cm
Identifiants
pubmed: 32103603
doi: 10.1111/iwj.13293
pmc: PMC7217204
doi:
Types de publication
Case Reports
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-752Subventions
Organisme : AVITA Medical
Informations de copyright
© 2020 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.
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