Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67-kDa Laminin Receptor Signaling.
Animals
Antineoplastic Agents, Phytogenic
/ pharmacology
Cell Proliferation
/ drug effects
Cyclic AMP-Dependent Protein Kinases
/ metabolism
Cytoskeleton
/ metabolism
Flavonoids
/ pharmacology
Intracellular Signaling Peptides and Proteins
/ metabolism
Melanoma, Experimental
/ drug therapy
Mice, Inbred C57BL
Muscle Proteins
/ metabolism
Myosin Light Chains
/ metabolism
Phosphorylation
/ drug effects
Protein Phosphatase 2
/ metabolism
Receptors, Laminin
/ metabolism
Procyanidin C1
epicatechin
melanoma
sensing molecules
wine polyphenols
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
07
10
2019
revised:
06
02
2020
pubmed:
28
2
2020
medline:
16
6
2021
entrez:
28
2
2020
Statut:
ppublish
Résumé
Procyanidin C1 (PC1) is an epicatechin trimer found mainly in grapes that is reported to provide several health benefits. However, little is known about the molecular mechanisms underlying these benefits. The aim of this study is to demonstrate the molecular mechanisms by which PC1 operates. A 67-kDa laminin receptor (67LR) is identified as a cell surface receptor of PC1, with a Kd value of 2.8 µm. PC1 induces an inhibitory effect on growth, accompanied by dephosphorylation of the C-kinase potentiated protein phosphatase-1 inhibitor protein of 17 kDa (CPI17) and myosin regulatory light chain (MRLC) proteins, followed by actin cytoskeleton remodeling in melanoma cells. These actions are mediated by protein kinase A (PKA) and protein phosphatase 2A (PP2A) activation once PC1 is bound to 67LR. It is demonstrated that PC1 elicits melanoma cell growth inhibition by activating the 67LR/PKA/PP2A/CPI17/MRLC pathway.
Identifiants
pubmed: 32103628
doi: 10.1002/mnfr.201900986
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Flavonoids
0
Intracellular Signaling Peptides and Proteins
0
Muscle Proteins
0
Myosin Light Chains
0
Ppp1r14a protein, mouse
0
Receptors, Laminin
0
procyanidin trimer C1
0
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Protein Phosphatase 2
EC 3.1.3.16
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900986Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
J. M. R. da Silva, J. Rigaud, V. Cheynier, A. Cheminat, M. Moutounet, Phytochemistry 1991, 30, 1259.
F. Gossé, S. Guyot, S. Roussi, A. Lobstein, B. Fischer, N. Seiler, F. Raul, Carcinogenesis 2005, 26, 1291.
T. Miura, M. Chiba, K. Kasai, H. Nozaka, T. Nakamura, T. Shoji, T. Kanda, Y. Ohtake, T. Sato, Carcinogenesis 2008, 29, 585.
Y. Nakamura, S. Tsuji, Y. Tonogai, J. Health Sci. 2003, 49, 45.
S. Tsukamoto, K. Hirotsu, M. Kumazoe, Y. Goto, K. Sugihara, T. Suda, Y. Tsurudome, T. Suzuki, S. Yamashita, Y. Kim, Y. Huang, K. Yamada, H. Tachibana, Biochem. J. 2012, 443, 525.
M. Kumazoe, K. Sugihara, S. Tsukamoto, Y. Huang, Y. Tsurudome, T. Suzuki, Y. Suemasu, N. Ueda, S. Yamashita, Y. Kim, K. Yamada, H. Tachibana, J. Clin. Invest. 2013, 123, 787.
M. Kumazoe, S. Tsukamoto, C. Lesnick, N. E. Kay, K. Yamada, T. D. Shanafelt, H. Tachibana, Br. J. Haematol. 2015, 168, 610.
H. Tachibana, K. Koga, Y. Fujimura, K. Yamada, Nat. Struct. Mol. Biol. 2004, 11, 380.
D. Umeda, S. Yano, K. Yamada, H. Tachibana, J. Biol. Chem. 2008, 283, 3050.
S. Tsukamoto, Y. Huang, D. Umeda, S. Yamada, S. Yamashita, M. Kumazoe, Y. Kim, M. Murata, K. Yamada, H. Tachibana, J. Biol. Chem. 2014, 289, 32671.
I. Mabuchi, M. Okuno, J. Cell Biol. 1977, 74, 251.
H. Suzuki, H. Onishi, K. Takahashi, S. Watanabe, J. Biochem. 1978, 84, 1529.
H. Kamisoyama, Y. Araki, M. Ikebe, Biochemistry 1994, 33, 840.
S. Elena, F. Cedric, B. Guy, S. benedicte, Dev. Cell 2018, 47, 727.
Q. Wu, R. M. Sahasrabudhe, L. Z. Luo, D. W. Lewis, S. M. Gollin, W. S. Saunders, Oncogene 2010, 29, 4183.
S. Pellegrin, H. Mellor, J. Cell Sci. 2007, 120, 3491.
B. I. Gerashchenko, K. Ueda, M. Hino, H. Hosoya, Cytometry 2002, 47, 150.
E. F. Etter, M. Eto, R. L. Wardle, D. L. Brautigan, R. A. Murphy, J. Biol. Chem. 2001, 276, 34681.
Y. Huang, M. Sumida, M. Kumazoe, K. Sugihara, Y. Suemasu, S. Yamada, S. Yamashita, J. Miyakawa, T. Takahashi, H. Tanaka, Y. Fujimuraa, H. Tachibana, Chem. Commun. 2017, 53, 1941.
S. Tsukamoto, S. Yamashita, Y. H. Kim, M. Kumazoe, Y. Huang, K. Yamada, H. Tachibana, FEBS Lett. 2012, 586, 3441.
M. Kumazoe, Y. Fujimura, S. Hidaka, Y. Kim, K. Murayama, M. Takai, Y. Huang, S. Yamashita, M. Murata, D. Miura, H. Wariishi, M. Maeda-Yamamoto, H. Tachibana, Sci. Rep. 2015, 5, 9474.
Y. Huang, M. Kumazoe, J. Bae, S. Yamada, M. Takai, S. Hidaka, S. Yamashita, Y. Kim, Y. Won, M. Murata, S. Tsukamoto, H. Tachibana, Oncol. Rep. 2015, 34, 1162.
J. Bae, M. Kumazoe, Y. Fujimura, H. Tachibana, J. Nutr. Biochem. 2019, 64, 152.
J. Bae, M. Kumazoe, S. Yamashita, H. Tachibana, Sci. Rep. 2017, 7, 6665.
Y. Fujimura, M. Sumida, K. Sugihara, S. Tsukamoto, K. Yamada, H. Tachibana, PLoS One 2012, 7, e37942.
H. Tachibana, Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 2011, 87, 66.
J. Muller, M. Pfaffl, BMC Complement Altern. Med. 2012, 12, 258.
E. W. Holy, S. F. Stämpfli, A. Akhmedov, N. Holm, G. G. Camici, T. F. Lüscher, F. C. Tanner, J. Mol. Cell. Cardiol. 2010, 48, 1138.
M. Kumazoe, Y. Nakamura, M. Yamashita, T. Suzuki, K. Takamatsu, Y. Huang, J. Bae, S. Yamashita, M. Murata, S. Yamada, Y. Shinoda, W. Yamaguchi, Y. Toyoda, H. Tachibana, J. Biol. Chem. 2017, 292, 4077.
Y. Fujimura, K. Yamada, H. Tachibana, Biochem. Biophys. Res. Commun. 2005, 336, 678.
M. Kumazoe, M. Yamashita, Y. Nakamura, K. Takamatsu, J. Bae, S. Yamashita, S. Yamada, H. Onda, T. Nojiri, K. Kangawa, H. Tachibana, J. Immunol. 2017, 199, 3261.
S. Menard, E. Tagliabue, M. I. Colnaghi, Breast Cancer Res. Treat. 1998, 52, 137.
X. Sanjuán, P. L. Fernández, R. Miquel, J. Muñoz, V. Castronovo, S. Ménard, A. Palacín, A. Cardesa, E. Campo, J Pathol 1996, 179, 376.
K. Mafune, T. S. Ravikumar, J. Surg. Res. 1992, 52, 340.
I. Vande Broek, K. Vanderkerken, C. De Greef, K. Asosingh, N. Straetmans, B. Van Camp, I. Van Riet, Br. J. Cancer 2001, 85, 1387.
M. Tanaka, K. Narumi, M. Isemura, M. Abe, Y. Sato, T. Abe, Y. Saijo, T. Nukiwa, K. Satoh, Cancer Lett. 2000, 153, 161.
S. Yamada, S. Tsukamoto, Y. Huang, A. Makio, M. Kumazoe, S. Yamashita, H. Tachibana, Sci. Rep. 2016, 6, 19225.
J. Nelson, N. V. McFerran, G. Pivato, E. Chambers, C. Doherty, D. Steele, D. J. Timson, Biosci. Rep. 2008, 28, 33.
S. Gauczynski, J. M. Peyrin, S. Haik, C. Leucht, C. Hundt, R. Reiger, S. Krasemann, J. P. Deslys, D. Dormont, C. I. Lasmezas, S. Weiss, EMBO J. 2001, 20, 5863.
K. S. Wang, R. J. Kuhn, E. G. Strauss, S. Ou, J. H. Strauss, J. Virol. 1992, 66, 4992.
C. Thepparit, D. R. Smith, J. Virol. 2004, 78, 12647.
B. Akache, D. Grimm, K. Pandey, S. R. Yant, H. Xu, M. A. Kay, J. Virol. 2006, 80, 9831.
X. Terra, P. Palozza, J. Fernandez-Larrea, A. Ardevol, C. Blade, G. Pujadas, J. Salvado, L. Arola, M. T. Blay, Free Radical Res. 2011, 45, 611.
L. Chin, L. A. Garraway, D. E. Fisher, Genes Dev. 2006, 20, 2149.
A. K. Salama, K. T. Flaherty, Clin. Cancer Res. 2013, 19, 4326.
H. Davies, G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Tea-gue, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton, P. A. Futreal, Nature 2002, 417, 949.
R. Nazarian, H. Shi, Q. Wang, X. Kong, R. C. Koya, H. Lee, Z. Chen, M. K. Lee, N. Attar, H. Sazegar, T. Chodon, S. F. Nelson, G. McArthur, J. A. Sosman, A. Ribas, R. S. Lo, Nature 2010, 468, 973.
S. Reagan-Shaw, M, Nihal, N. Ahmad, FASEB J. 2008, 22, 659.
R. C. Khanal, L. R. Howard, R. L. Prior, J. Food Sci. 2009, 76, 174.
M. Kumazoe, M. Takai, S. Hiroi, C. Takeuchi, M. Kadomatsu, T. Nojiri, H. Onda, J. Bae, Y. Huang, K. Takamatsu, S. Yamashita, K. Kangawa, H. Tachibana, J. Biol. Chem. 2017, 292, 10813.