Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth.
Aminopyridines
/ administration & dosage
Animals
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Benzimidazoles
/ administration & dosage
Cyclin D
/ metabolism
Cyclin-Dependent Kinase 4
/ antagonists & inhibitors
Humans
Lung Neoplasms
/ drug therapy
Mice
Mice, Nude
Mutation
Optical Imaging
/ methods
Peptides
/ administration & dosage
Proto-Oncogene Proteins p21(ras)
/ drug effects
CDK4
Inhibitor
KRAS mutation
Lung cancer (NSCLC)
Stapled Peptide
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
10
2019
accepted:
19
11
2019
entrez:
28
2
2020
pubmed:
28
2
2020
medline:
15
4
2021
Statut:
epublish
Résumé
CDK4/cyclin D kinase constitutes an attractive pharmacological target for development of anticancer therapeutics, in particular in
Identifiants
pubmed: 32104498
doi: 10.7150/thno.40971
pii: thnov10p2008
pmc: PMC7019173
doi:
Substances chimiques
Aminopyridines
0
Benzimidazoles
0
Cyclin D
0
KRAS protein, human
0
Peptides
0
abemaciclib
60UAB198HK
CDK4 protein, human
EC 2.7.11.22
Cyclin-Dependent Kinase 4
EC 2.7.11.22
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2008-2028Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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