A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer's Amyloid-
Alzheimer Disease
/ drug therapy
Amyloid beta-Peptides
/ metabolism
Cell Line, Tumor
Cellular Senescence
/ drug effects
Humans
Membrane Potential, Mitochondrial
/ drug effects
Mitochondria
/ drug effects
Mitochondrial Proton-Translocating ATPases
/ metabolism
Neurons
/ drug effects
Oxidative Stress
/ drug effects
Oxygen
/ metabolism
Peptide Fragments
/ metabolism
Proscillaridin
/ analogs & derivatives
Reactive Oxygen Species
/ metabolism
Sirtuin 3
/ antagonists & inhibitors
Superoxide Dismutase
/ metabolism
Up-Regulation
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
09
2019
revised:
23
12
2019
accepted:
10
01
2020
entrez:
28
2
2020
pubmed:
28
2
2020
medline:
11
11
2020
Statut:
epublish
Résumé
Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer's disease (AD), and oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 is a mitochondrial protein regulating metabolic enzyme activity by deacetylation and its downregulation is associated with AD pathology. In the present study, we showed that a newly synthesized rhamnoside derivative PL171 inhibited the generation of reactive oxidant species (ROS) induced by amyloid-
Identifiants
pubmed: 32104538
doi: 10.1155/2020/7698560
pmc: PMC7040408
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Reactive Oxygen Species
0
amyloid beta-protein (1-42)
0
Superoxide Dismutase
EC 1.15.1.1
Sirtuin 3
EC 3.5.1.-
Mitochondrial Proton-Translocating ATPases
EC 3.6.3.-
oligomycin sensitivity-conferring protein
EC 7.1.2.2
Proscillaridin
KC6BL281EN
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7698560Informations de copyright
Copyright © 2020 Yi Li et al.
Déclaration de conflit d'intérêts
PX is a full-time employee of Shanghai EW Medicine Co., Ltd. The remaining authors declare no competing financial interests.
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