Sicca Symptoms in Parkinson's Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life.
Journal
Parkinson's disease
ISSN: 2090-8083
Titre abrégé: Parkinsons Dis
Pays: United States
ID NLM: 101539877
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
09
2019
revised:
11
12
2019
accepted:
22
01
2020
entrez:
28
2
2020
pubmed:
28
2
2020
medline:
28
2
2020
Statut:
epublish
Résumé
Frequently used nonmotor scales do not cover all aspects of dysautonomia in Parkinson's disease (PD). This study explores the association between autonomic symptoms and sicca symptoms with other nonmotor symptoms and health-related quality of life (QoL) in PD. Autonomic symptoms (Survey of Autonomic Symptoms, SASs), motor function (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale III, MDS-UPDRS III), nonmotor symptoms (nonmotor symptoms questionnaire, NMS-Quest), and QoL (PD Questionnaire-39, PDQ-39) were analysed in 93 PD patients without dementia. Multivariable and multivariate analyses were performed to study the association between clinical parameters and PDQ-39 domains. Among the autonomic symptoms, sicca symptoms (xerostomia and dry eyes) were the most commonly reported (69%), followed by sexual dysfunction in men, leaking of urine, vasomotor dysfunction, constipation, sudomotor dysfunction, and orthostatic symptoms. The autonomic symptom burden (SAS total) correlated with the NMS-Quest and Hoehn and Yahr stage, but not with age, levodopa equivalent daily dose, disease duration, and the MDS-UPDRS III. The SAS total score was an independent predictor of the PDQ-39 summary index and mainly affected the PDQ-39 cognition and emotional well-being domains. Sicca symptoms were not associated with age, MDS-UPDRS III, disease duration, Hoehn and Yahr stage, and levodopa equivalent daily dose but aggravated the PDQ-39 domains: cognition, emotional well-being, bodily discomfort, and mobility. Sicca symptoms frequently occur together with other nonmotor symptoms, namely, urine urgency, orthostatic problems, and concentration problems. Overall, 75% of the subjects took at least one drug that can cause sicca symptoms (anti-PD medication, antidepressant drugs, antihypertensive drugs, antipsychotic drugs, antimuscarinic drugs, and analgesic drugs). Sicca symptoms are common in PD and negatively influence QoL. The observed association between sicca symptoms and other nonmotor symptoms provides further preliminary evidence for the growing recognition of different nonmotor clusters in PD.
Sections du résumé
BACKGROUND
BACKGROUND
Frequently used nonmotor scales do not cover all aspects of dysautonomia in Parkinson's disease (PD). This study explores the association between autonomic symptoms and sicca symptoms with other nonmotor symptoms and health-related quality of life (QoL) in PD.
METHODS
METHODS
Autonomic symptoms (Survey of Autonomic Symptoms, SASs), motor function (Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale III, MDS-UPDRS III), nonmotor symptoms (nonmotor symptoms questionnaire, NMS-Quest), and QoL (PD Questionnaire-39, PDQ-39) were analysed in 93 PD patients without dementia. Multivariable and multivariate analyses were performed to study the association between clinical parameters and PDQ-39 domains.
RESULTS
RESULTS
Among the autonomic symptoms, sicca symptoms (xerostomia and dry eyes) were the most commonly reported (69%), followed by sexual dysfunction in men, leaking of urine, vasomotor dysfunction, constipation, sudomotor dysfunction, and orthostatic symptoms. The autonomic symptom burden (SAS total) correlated with the NMS-Quest and Hoehn and Yahr stage, but not with age, levodopa equivalent daily dose, disease duration, and the MDS-UPDRS III. The SAS total score was an independent predictor of the PDQ-39 summary index and mainly affected the PDQ-39 cognition and emotional well-being domains. Sicca symptoms were not associated with age, MDS-UPDRS III, disease duration, Hoehn and Yahr stage, and levodopa equivalent daily dose but aggravated the PDQ-39 domains: cognition, emotional well-being, bodily discomfort, and mobility. Sicca symptoms frequently occur together with other nonmotor symptoms, namely, urine urgency, orthostatic problems, and concentration problems. Overall, 75% of the subjects took at least one drug that can cause sicca symptoms (anti-PD medication, antidepressant drugs, antihypertensive drugs, antipsychotic drugs, antimuscarinic drugs, and analgesic drugs).
CONCLUSION
CONCLUSIONS
Sicca symptoms are common in PD and negatively influence QoL. The observed association between sicca symptoms and other nonmotor symptoms provides further preliminary evidence for the growing recognition of different nonmotor clusters in PD.
Identifiants
pubmed: 32104559
doi: 10.1155/2020/2958635
pmc: PMC7038154
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2958635Informations de copyright
Copyright © 2020 Tino Prell et al.
Déclaration de conflit d'intérêts
The authors report that there are no conflicts of interest related to this manuscript.
Références
Int J Clin Pharm. 2018 Feb;40(1):94-100
pubmed: 29147963
Parkinsonism Relat Disord. 2016 Mar;24:113-8
pubmed: 26774535
J Parkinsons Dis. 2011;1(2):169-73
pubmed: 23939300
Auton Neurosci. 2001 Sep 17;92(1-2):76-85
pubmed: 11570707
Expert Rev Neurother. 2015 Oct;15(10):1189-203
pubmed: 26416396
Spec Care Dentist. 2008 Nov-Dec;28(6):224-36
pubmed: 19068063
Oral Dis. 2017 May;23(4):464-470
pubmed: 27976483
Lancet Neurol. 2006 Mar;5(3):235-45
pubmed: 16488379
Mov Disord. 2018 Mar;33(3):391-397
pubmed: 29278286
Arch Gerontol Geriatr. 2014 Nov-Dec;59(3):630-5
pubmed: 25192614
J Parkinsons Dis. 2019;9(2):405-411
pubmed: 30909249
Acta Neurol Belg. 2017 Mar;117(1):207-211
pubmed: 28028676
Nat Rev Neurosci. 2017 Aug;18(8):509
pubmed: 28720825
Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S41-6
pubmed: 26459660
Gerodontology. 2005 Dec;22(4):219-26
pubmed: 16329230
J Am Dent Assoc. 2009 Jun;140(6):658-69
pubmed: 19491161
Ann Acad Med Stetin. 2011;57(1):11-5; discussion 16
pubmed: 22593985
J Neurol. 1998 May;245 Suppl 1:S10-4
pubmed: 9617716
Clin Dermatol. 2017 Sep - Oct;35(5):468-476
pubmed: 28916028
Front Neurol. 2017 Oct 30;8:551
pubmed: 29163328
Front Aging Neurosci. 2017 Sep 20;9:301
pubmed: 28979203
Gerodontology. 2017 Mar;34(1):135-143
pubmed: 27231151
Parkinsonism Relat Disord. 2014 Nov;20(11):1236-41
pubmed: 25260967
J Neurol. 2003 Feb;250 Suppl 1:I28-30
pubmed: 12761632
Mov Disord. 2007 Jan;22(1):41-7
pubmed: 17115387
Parkinsonism Relat Disord. 2013 Nov;19(11):1027-32
pubmed: 23916654
Neurology. 2011 Mar 22;76(12):1099-105
pubmed: 21422460
Clin Auton Res. 2015 Oct;25(5):301-7
pubmed: 26359270
Mov Disord. 2010 Nov 15;25(15):2493-500
pubmed: 20922807
Neurology. 2007 Jul 24;69(4):333-41
pubmed: 17646625
Mov Disord. 2016 Jul;31(7):937-46
pubmed: 27091624