Prevalence and Prognostic Impact of Hypernatremia in Sepsis and Septic Shock Patients in the Intensive Care Unit: A Single Centre Experience.
biomarkers
hypernatremia
sepsis
Journal
Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)
ISSN: 2393-1809
Titre abrégé: J Crit Care Med (Targu Mures)
Pays: Poland
ID NLM: 101706934
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
19
10
2019
accepted:
12
01
2020
entrez:
28
2
2020
pubmed:
28
2
2020
medline:
28
2
2020
Statut:
epublish
Résumé
Hypernatremia is a commonly associated electrolyte disturbance in sepsis and septic shock patients in the ICU. The objective of this study was to identify the prognostic value of hypernatremia in sepsis and septic shock. A prospective study conducted on sepsis and septic shock patients diagnosed prior to admission in the ICU in King Hamad University Hospital, Bahrain from January 1st 2017 to February 28th 2019. Data including age, sex, comorbidities, source of sepsis, sodium levels on days one, three, and seven. Data was correlated with the outcome (survival/death and the length of ICU stay). Patients included were 168, 110 survived, and 58 died. Hypernatraemia at day seven was associated with significantly higher mortality (P= 0.03). Hypernatraemia at Day1was associated with a significantly prolonged stay in the ICU (p= 0.039).Multivariate analysis to identify the independent predictors of mortality revealed that immunosuppression and hypernatraemia at Day7 proved to be independent predictors of mortality (P= 0.026 and 0.039 respectively). Hypernatremia can be an independent predictor of poor outcome in septic and septic shock patients in the ICU.
Identifiants
pubmed: 32104731
doi: 10.2478/jccm-2020-0001
pii: jccm-2020-0001
pmc: PMC7029404
doi:
Types de publication
Journal Article
Langues
eng
Pagination
52-58Informations de copyright
© 2020 Mohamed Shirazy, Islam Omar, Duaa Abduljabbar, Kamel Bousselmi, Maryam Alkhaja, Anis Chaari, Vipin Kauts, Karim Hakim, published by Sciendo.
Déclaration de conflit d'intérêts
Conflict of interest None to declare.
Références
Crit Care Med. 1999 Jun;27(6):1105-8
pubmed: 10397213
PLoS One. 2015 May 06;10(5):e0125827
pubmed: 25946168
Intensive Care Med. 2015 Sep;41(9):1620-8
pubmed: 26109396
Intensive Care Med. 2010 Oct;36(10):1718-23
pubmed: 20658124
JAMA. 2017 Oct 3;318(13):1241-1249
pubmed: 28903154
JAMA. 2016 Feb 23;315(8):775-87
pubmed: 26903336
Nephrol Dial Transplant. 2010 Aug;25(8):2510-5
pubmed: 20167570
Hemodial Int. 2012 Oct;16(4):559-63
pubmed: 22515501
Lung India. 2015 Jul-Aug;32(4):313-9
pubmed: 26180378
J Crit Care. 2013 Aug;28(4):405-12
pubmed: 23369520
Crit Care Med. 2006 Nov;34(11):2707-13
pubmed: 16943733
Nephrol Dial Transplant. 2012 Mar;27(3):962-7
pubmed: 21810766
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Acta Anaesthesiol Scand. 2014 Sep;58(8):1007-14
pubmed: 25039806
Crit Care Med. 2018 Aug;46(8):1334-1356
pubmed: 29957716
Nephrol Dial Transplant. 2008 May;23(5):1562-8
pubmed: 18065827
Am J Kidney Dis. 2009 Oct;54(4):674-9
pubmed: 19515476
Crit Care Med. 2014 Aug;42(8):1749-55
pubmed: 24717459
N Engl J Med. 2017 Jun 8;376(23):2235-2244
pubmed: 28528569
Am J Med Sci. 2016 Jun;351(6):601-5
pubmed: 27238923
Am J Kidney Dis. 2007 Dec;50(6):952-7
pubmed: 18037096
Crit Care Med. 2017 Mar;45(3):395-406
pubmed: 27941371
Crit Care Med. 2006 Jun;34(6):1589-96
pubmed: 16625125
Am J Respir Crit Care Med. 2016 Jun 1;193(11):1264-70
pubmed: 26695114
Clin Exp Nephrol. 2008 Feb;12(1):74-8
pubmed: 18180873
Anaesthesia. 2010 Mar;65(3):283-93
pubmed: 20085566
N Engl J Med. 2000 May 18;342(20):1493-9
pubmed: 10816188
Crit Care Med. 2015 Jan;43(1):3-12
pubmed: 25275252
Am J Nephrol. 1993;13(4):260-5
pubmed: 8267023
Best Pract Res Clin Endocrinol Metab. 2016 Mar;30(2):189-203
pubmed: 27156758
Crit Care. 2014 Feb 12;18(1):108
pubmed: 24517597
Crit Care Med. 2017 Mar;45(3):486-552
pubmed: 28098591
Electrolyte Blood Press. 2010 Dec;8(2):72-81
pubmed: 21468200
Crit Care Med. 2016 Apr;44(4):e234-5
pubmed: 26974458
Anaesthesia. 2009 May;64(5):514-20
pubmed: 19413821