Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-Linked Diubiquitin by a Twofold Strategy.
RaPID system
diubiquitin
macrocyclic peptides
messenger RNA display
proteasome
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
16
01
2020
pubmed:
28
2
2020
medline:
1
8
2020
entrez:
28
2
2020
Statut:
ppublish
Résumé
Messenger RNA display of peptides containing non-proteinogenic amino acids, referred to as RaPID system, has become one of the leading methods to express libraries consisting of more than trillion-members of macrocyclic peptides, which allows for discovering de novo bioactive ligands. Ideal macrocyclic peptides should have dissociation constants (K
Identifiants
pubmed: 32105365
doi: 10.1002/chem.202000273
doi:
Substances chimiques
Amino Acids
0
Peptide Library
0
Peptides
0
UBD protein, human
0
Ubiquitins
0
Proteasome Endopeptidase Complex
EC 3.4.25.1
ATP dependent 26S protease
EC 3.4.99.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8022-8027Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP19am0301001; JP19am0101090
Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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