Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron.
4-hydroxynonenal
ferroptosis
iron
nanomedicine
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
25 Feb 2020
25 Feb 2020
Historique:
received:
29
01
2020
revised:
19
02
2020
accepted:
21
02
2020
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
29
2
2020
Statut:
epublish
Résumé
Traditional concepts of life sciences consider oxidative stress as a fundamental process of aging and various diseases including cancer, whereas traditional medicine recommends dietary intake of iron to support physiological functions of the organism. However, due to its strong pro-oxidative capacity, if not controlled well, iron can trigger harmful oxidative stress manifested eventually by toxic chain reactions of lipid peroxidation. Such effects of iron are considered to be major disadvantages of uncontrolled iron usage, although ferroptosis seems to be an important defense mechanism attenuating cancer development. Therefore, a variety of iron-containing nanoparticles were developed for experimental radio-, chemo-, and photodynamic as well as magnetic dynamic nanosystems that alter redox homeostasis in cancer cells. Moreover, studies carried over recent decades have revealed that even the end products of lipid peroxidation, represented by 4-hydroxynonenal (4-HNE), could have desirable effects even acting as kinds of selective anticancer substances produced by non-malignant cells for defense again invading cancer. Therefore, advanced nanotechnologies should be developed for using iron to trigger targeted lipid peroxidation as an anticancer option of integrative biomedicine.
Identifiants
pubmed: 32106528
pii: antiox9030191
doi: 10.3390/antiox9030191
pmc: PMC7139573
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Pharm Res. 2016 Oct;33(10):2373-87
pubmed: 27299311
Nanoscale. 2019 Aug 8;11(31):14654-14667
pubmed: 31355836
Toxicol Lett. 1995 Dec;82-83:969-74
pubmed: 8597169
Cell. 2017 Oct 5;171(2):273-285
pubmed: 28985560
Environ Mol Mutagen. 2015 Mar;56(2):125-48
pubmed: 25209650
Chem Biol Interact. 2019 Oct 1;312:108814
pubmed: 31509734
Free Radic Biol Med. 2015 Apr;81:128-44
pubmed: 25619142
Antioxid Redox Signal. 2013 Jun 20;18(18):2473-507
pubmed: 23199217
Angew Chem Int Ed Engl. 2019 Jan 21;58(4):946-956
pubmed: 30048028
Redox Rep. 2007;12(1):50-4
pubmed: 17263909
Antioxidants (Basel). 2018 Sep 21;7(10):
pubmed: 30241411
ACS Appl Mater Interfaces. 2019 Aug 21;11(33):29579-29592
pubmed: 31359756
Free Radic Biol Med. 2017 Oct;111:110-126
pubmed: 27993730
ACS Nano. 2019 Sep 24;13(9):10002-10014
pubmed: 31433945
Materials (Basel). 2019 Feb 19;12(4):
pubmed: 30791358
Int J Mol Sci. 2017 Apr 29;18(5):
pubmed: 28468256
EMBO J. 1989 Dec 1;8(12):3693-9
pubmed: 2583116
J Hematol Oncol. 2019 Mar 29;12(1):34
pubmed: 30925886
J Biol Chem. 2003 May 16;278(20):17646-54
pubmed: 12637578
ACS Appl Mater Interfaces. 2019 Jan 9;11(1):385-393
pubmed: 30556390
J Nanobiotechnology. 2019 Jun 13;17(1):75
pubmed: 31196217
J Biol Chem. 2008 Feb 22;283(8):4578-87
pubmed: 18160403
Cell Metab. 2012 Jun 6;15(6):895-904
pubmed: 22633452
Theranostics. 2019 Feb 12;9(5):1288-1302
pubmed: 30867831
ACS Appl Mater Interfaces. 2019 Nov 20;11(46):42873-42884
pubmed: 31553151
Free Radic Res. 2013 Aug;47 Suppl 1:39-48
pubmed: 23521622
Arch Biochem Biophys. 1992 Nov 1;298(2):438-45
pubmed: 1416975
Adv Healthc Mater. 2018 Apr;7(8):e1701156
pubmed: 29283221
Int J Hyperthermia. 2010;26(8):790-5
pubmed: 20653418
Cell Metab. 2011 Nov 2;14(5):647-57
pubmed: 22055506
Biomaterials. 2019 Dec;224:119498
pubmed: 31557590
Biomaterials. 2016 Dec;109:55-68
pubmed: 27669498
Anticancer Res. 2003 Mar-Apr;23(2B):1589-95
pubmed: 12820427
J Biol Chem. 1996 Sep 27;271(39):24226-30
pubmed: 8798666
FEBS Lett. 2001 Dec 7;509(2):309-16
pubmed: 11741608
Cell Chem Biol. 2018 Apr 19;25(4):413-425.e6
pubmed: 29398562
Cold Spring Harb Perspect Biol. 2013 Aug 01;5(8):a011312
pubmed: 23906713
Biomaterials. 2019 Sep;214:119223
pubmed: 31174065
Med Oncol. 2010 Jun;27(2):268-77
pubmed: 19308738
Biochim Biophys Acta. 1999 Nov 10;1413(3):99-107
pubmed: 10556622
Free Radic Biol Med. 2017 Jan;102:67-76
pubmed: 27838437
Life Sci. 2018 Feb 15;195:71-80
pubmed: 29289560
Cell. 2014 Jan 16;156(1-2):317-331
pubmed: 24439385
Nat Nanotechnol. 2007 Sep;2(9):577-83
pubmed: 18654371
Biochim Biophys Acta. 2008 Nov;1780(11):1318-24
pubmed: 18395525
J Proteomics. 2013 Oct 30;92:239-47
pubmed: 23438936
J Alzheimers Dis. 2010;20 Suppl 2:S551-68
pubmed: 20463401
Biofactors. 2005;24(1-4):141-8
pubmed: 16403974
Theranostics. 2019 Aug 14;9(21):6209-6223
pubmed: 31534546
Redox Biol. 2017 Apr;11:600-605
pubmed: 28110216
Nitric Oxide. 2004 Nov;11(3):256-62
pubmed: 15566972
Nanomaterials (Basel). 2017 Oct 05;7(10):
pubmed: 28981476
Chem Rev. 2019 Mar 27;119(6):4357-4412
pubmed: 30801188
Adv Sci (Weinh). 2019 Jan 18;6(5):1801986
pubmed: 30886808
Free Radic Res. 2015;49(7):850-60
pubmed: 25532703
Immunobiology. 2009;214(2):121-8
pubmed: 19167990
Nanomedicine (Lond). 2010 Nov;5(9):1401-14
pubmed: 21128722
Cell Chem Biol. 2016 Feb 18;23(2):225-235
pubmed: 26853626
Toxicol In Vitro. 2011 Feb;25(1):160-6
pubmed: 21044880
Free Radic Biol Med. 2017 Mar;104:129-137
pubmed: 28088621
J Photochem Photobiol B. 2019 Dec;201:111648
pubmed: 31710924
Anticancer Res. 2001 May-Jun;21(3B):1997-2004
pubmed: 11497289
Cell Metab. 2013 Mar 5;17(3):319-28
pubmed: 23473029
Chem Res Toxicol. 1999 Jan;12(1):83-92
pubmed: 9894022
Cancer Cell. 2019 Jun 10;35(6):830-849
pubmed: 31105042
J Am Acad Dermatol. 2009 Feb;60(2):270-6
pubmed: 19028405
Environ Toxicol. 2018 Oct;33(10):1078-1088
pubmed: 30098274
Cell Biochem Biophys. 2013 Nov;67(2):461-76
pubmed: 22669739
Free Radic Biol Med. 2019 Nov 19;:
pubmed: 31756524
Free Radic Biol Med. 2017 Jul;108:610-626
pubmed: 28433662
Int J Nanomedicine. 2017 Jun 06;12:4257-4268
pubmed: 28652731
Mol Pharm. 2019 Nov 4;:
pubmed: 31613630
Biol Trace Elem Res. 2014 Jun;159(1-3):416-24
pubmed: 24748114
Biomaterials. 2019 Oct;219:119369
pubmed: 31351244
Materials (Basel). 2019 Feb 02;12(3):
pubmed: 30717431
Einstein (Sao Paulo). 2019 Aug 01;17(4):eAO4786
pubmed: 31390427
Int J Mol Sci. 2020 Jan 31;21(3):
pubmed: 32023985
J Mater Chem B. 2019 Apr 7;7(13):2190-2200
pubmed: 32073578
Int J Mol Sci. 2018 Dec 27;20(1):
pubmed: 30591630
Biochim Biophys Acta Gen Subj. 2020 Mar;1864(3):129487
pubmed: 31734461
J Control Release. 2019 Sep 10;309:145-157
pubmed: 31348976
Biochem Biophys Res Commun. 2015 Dec 18;468(3):504-10
pubmed: 26260323
Sci Rep. 2019 May 6;9(1):6912
pubmed: 31061500
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
Front Pharmacol. 2018 Jan 12;8:992
pubmed: 29375387
Cancer Lett. 2008 Feb 18;260(1-2):180-6
pubmed: 18083303
Front Biosci (Landmark Ed). 2016 Jan 01;21:839-55
pubmed: 26709808