Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.
Alzheimer's disease
CSF clearance
CSF proteins
Choroid plexus
Parkinson's disease
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
16
05
2019
revised:
06
01
2020
accepted:
13
01
2020
pubmed:
29
2
2020
medline:
24
9
2020
entrez:
29
2
2020
Statut:
ppublish
Résumé
The choroid plexus (ChP) is a major source of cerebrospinal fluid (CSF) production, with a direct and indirect role in protein clearance, and pathogenesis of Alzheimer's disease (AD). Here, we tested the link between the ChP volume and levels of CSF proteins in 2 data sets of (i) healthy controls, mild cognitive impairment (MCI), and AD patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) (N = 509), and (ii) healthy controls and Parkinson's disease (PD) patients from the Parkinson's Progression Markers Initiative (N = 302). All patients had baseline CSF proteins (amyloid-β, total and phosphorylated-tau and α-synuclein (only in Parkinson's Progression Markers Initiative)). ChP was automatically segmented on 3T structural T1-weighted MRIs. We found negative associations between ChP volume and CSF proteins, which were stronger in healthy controls, early-MCI patients, and PD patients compared with late-MCI and AD patients. Further grouping of patients of ADNI dataset into amyloid-positive and amyloid-negative based on their florbetapir (AV45) PET imaging showed that the association between ChP volume and CSF proteins (t/p-tau) was lower in amyloid-positive group. Our findings support the possible role of ChP in the clearance of CSF proteins, provide evidence for ChP dysfunction in AD, and suggest the need to account for the ChP volume in future studies of CSF-based biomarkers.
Identifiants
pubmed: 32107064
pii: S0197-4580(20)30013-0
doi: 10.1016/j.neurobiolaging.2020.01.005
pmc: PMC9094632
mid: NIHMS1789639
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
alpha-Synuclein
0
tau Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108-117Subventions
Organisme : NINDS NIH HHS
ID : R21 NS085491
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS082870
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073601
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH099196
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD069776
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG060981
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
Fluids Barriers CNS. 2015 Oct 05;12:23
pubmed: 26435380
JAMA Neurol. 2015 Oct;72(10):1183-90
pubmed: 26280102
Neurochem Res. 2015 Dec;40(12):2583-99
pubmed: 25947369
J Alzheimers Dis. 2017;56(2):543-555
pubmed: 28059783
J Alzheimers Dis. 2010;20(2):647-57
pubmed: 20182051
Exp Eye Res. 1977;25 Suppl:461-73
pubmed: 590401
J Alzheimers Dis. 2017;58(3):821-828
pubmed: 28505972
Elife. 2018 Jul 31;7:
pubmed: 30063207
Nat Rev Neurol. 2015 Aug;11(8):457-70
pubmed: 26195256
Int J Geriatr Psychiatry. 2010 Apr;25(4):403-10
pubmed: 19650161
Exp Biol Med (Maywood). 2005 Nov;230(10):771-6
pubmed: 16246905
Ann Neurol. 2013 Dec;74(6):826-36
pubmed: 23536396
Physiol Rev. 2013 Oct;93(4):1847-92
pubmed: 24137023
Front Pharmacol. 2012 May 03;3:75
pubmed: 22563316
Acta Neurol Scand. 2017 Jan;135(1):34-56
pubmed: 26991855
Neurol India. 2003 Sep;51(3):379-82
pubmed: 14652445
Neural Regen Res. 2016 Apr;11(4):534-7
pubmed: 27212900
PLoS One. 2018 Feb 7;13(2):e0191240
pubmed: 29415068
Data Brief. 2017 Oct 16;15:648-657
pubmed: 29124088
J Mol Neurosci. 2015 Jul;56(3):708-21
pubmed: 25634726
Nat Rev Neurol. 2010 Mar;6(3):131-44
pubmed: 20157306
Neuron. 2013 Dec 18;80(6):1347-58
pubmed: 24360540
Neurology. 2016 Jan 19;86(3):286-96
pubmed: 26683646
Mt Sinai J Med. 2010 Jan-Feb;77(1):32-42
pubmed: 20101720
Brain. 2010 Mar;133(Pt 3):713-26
pubmed: 20157014
Curr Aging Sci. 2010 Dec;3(3):219-29
pubmed: 20735345
Oncol Lett. 2017 Mar;13(3):1479-1485
pubmed: 28454280
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
J Neurochem. 2011 Aug;118(3):407-15
pubmed: 21585370
Sci Rep. 2015 Sep 21;5:14329
pubmed: 26388497
Cell Mol Life Sci. 2014 Aug;71(15):2947-55
pubmed: 24343520
Science. 2010 Dec 24;330(6012):1774
pubmed: 21148344
AJNR Am J Neuroradiol. 2015 Sep;36(9):1786-90
pubmed: 26021621