Dasatinib Is an Effective Treatment for Angioimmunoblastic T-cell Lymphoma.

Aged Animals Antineoplastic Agents / administration & dosage DNA-Binding Proteins / genetics Dasatinib / administration & dosage Dioxygenases Disease Models, Animal Drug Administration Schedule Female Humans Immunoblastic Lymphadenopathy / blood Interferon-gamma / blood Interleukins / blood Lymphoma, T-Cell / blood Male Mice Mice, Inbred BALB C Mice, Nude Mice, Transgenic Middle Aged Proto-Oncogene Proteins / genetics Proto-Oncogene Proteins c-vav / genetics Receptors, Antigen, T-Cell / drug effects Tumor Necrosis Factor-alpha / blood rhoA GTP-Binding Protein / genetics

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 05 2020
Historique:
received: 05 09 2019
revised: 25 12 2019
accepted: 25 02 2020
pubmed: 29 2 2020
medline: 21 10 2020
entrez: 29 2 2020
Statut: ppublish

Résumé

Recurrent hotspot (p.Gly17Val) mutations in

Identifiants

DOI: 10.1158/0008-5472.CAN-19-2787 PMID: 32107212
pubmed: 32107212
pii: 0008-5472.CAN-19-2787
doi: 10.1158/0008-5472.CAN-19-2787
doi:

Substances chimiques

Antineoplastic Agents 0
DNA-Binding Proteins 0
Interleukins 0
Proto-Oncogene Proteins 0
Proto-Oncogene Proteins c-vav 0
Receptors, Antigen, T-Cell 0
Tumor Necrosis Factor-alpha 0
VAV1 protein, human 0
Interferon-gamma 82115-62-6
Dioxygenases EC 1.13.11.-
TET2 protein, human EC 1.13.11.-
Tet2 protein, mouse EC 1.13.11.-
rhoA GTP-Binding Protein EC 3.6.5.2
Dasatinib RBZ1571X5H

Types de publication

Clinical Trial, Phase I Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1875-1884

Informations de copyright

©2020 American Association for Cancer Research.

Auteurs

Tran B Nguyen (TB)

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Mamiko Sakata-Yanagimoto (M)

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. schiba-tky@umin.net sakatama-tky@umin.net.
Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Manabu Fujisawa (M)

Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Sharna Tanzima Nuhat (ST)

Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Hiroaki Miyoshi (H)

Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan.
ORCID: 0000-0002-2356-3725

Yasuhito Nannya (Y)

Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.

Koichi Hashimoto (K)

Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Kota Fukumoto (K)

Department of Hematology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Olivier A Bernard (OA)

INSERM U1170, Gustave Roussy, Université Paris-Saclay, Equipe Labellisée Ligue Nationale Contre le Cancer, Villejuif, France.

Yusuke Kiyoki (Y)

Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
ORCID: 0000-0002-9539-0237

Kantaro Ishitsuka (K)

Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Haruka Momose (H)

Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Shinichiro Sukegawa (S)

Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Atsushi Shinagawa (A)

Department of Hematology, Hitachi General Hospital, Hitachi, Ibaraki, Japan.

Takuya Suyama (T)

Department of Hematology, Hitachi General Hospital, Hitachi, Ibaraki, Japan.
ORCID: 0000-0002-0783-5073

Yuji Sato (Y)

Department of Hematology, Tsukuba Memorial Hospital, Tsukuba, Ibaraki, Japan.

Hidekazu Nishikii (H)

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Naoshi Obara (N)

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Manabu Kusakabe (M)

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.

Shintaro Yanagimoto (S)

Division for Health Service Promotion, University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Seishi Ogawa (S)

Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan.

Koichi Ohshima (K)

Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka, Japan.

Shigeru Chiba (S)

Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. schiba-tky@umin.net sakatama-tky@umin.net.
Department of Hematology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Eucaryotes › Animaux › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Dasatinib › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Calendrier d'administration des médicaments › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphadénopathie angio-immunoblastique › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome T › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-vav › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Dasatinib Is an Effective Treatment for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéine G RhoA › Dasatinib Is an Effective Treatment for...