Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 02 2020
27 02 2020
Historique:
received:
19
07
2019
accepted:
10
02
2020
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
21
11
2020
Statut:
epublish
Résumé
To determine the relationship between psychological stress with cognitive outcomes in a multi-centre longitudinal study of people with amnestic mild cognitive impairment (aMCI) we assessed three parameters of psychological stress (Recent Life Changes Questionnaire (RLCQ); the Perceived Stress Scale (PSS) and salivary cortisol) and their relationship with rates of cognitive decline over an 18 month follow up period and conversion to dementia over a 5.5 year period. In 133 aMCI and 68 cognitively intact participants the PSS score was higher in the aMCI compared with control group but neither the RLCQ scores nor salivary cortisol measures were different between groups. In the aMCI group the RLCQ and the PSS showed no significant association with cognitive function at baseline, cognitive decline or with conversion rates to dementia but high salivary cortisol levels were associated with RLCQ scores and poorer cognitive function at baseline and lower rates of cognitive decline. No relationship was found between salivary cortisol levels and conversion rate to dementia. We conclude that psychological stress as measured by the RLCQ or PSS was not associated with adverse cognitive outcomes in an aMCI population and hypothesise that this may reflect diminished cortisol production to psychological stress as the disease progresses.
Identifiants
pubmed: 32108148
doi: 10.1038/s41598-020-60607-0
pii: 10.1038/s41598-020-60607-0
pmc: PMC7046646
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
3618Subventions
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
Organisme : Alzheimer's Society
ID : PG 143/150
Pays : International
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