Outcome of allogeneic haematopoietic stem cell transplantation in myeloproliferative neoplasm, unclassifiable: a retrospective study by the Chronic Malignancies Working Party of the EBMT.
Adult
Aged
Databases, Factual
Female
Follow-Up Studies
Hematopoietic Stem Cell Transplantation
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Mutation
Myeloproliferative Disorders
/ genetics
Recurrence
Retrospective Studies
Risk
Societies, Scientific
Transplantation Conditioning
Transplantation, Homologous
Treatment Outcome
Young Adult
allogeneic stem cell transplant
conditioning
myeloproliferative neoplasms unclassifiable
non-relapse mortality
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
13
11
2019
revised:
15
01
2020
accepted:
20
01
2020
pubmed:
29
2
2020
medline:
4
3
2021
entrez:
29
2
2020
Statut:
ppublish
Résumé
Myeloproliferative Neoplasm (MPN), unclassifiable (MPN-U) is a heterogeneous disease with regards to both clinical phenotype and disease course. Patients may initially be asymptomatic or present with leucocytosis or thrombocytosis, anaemia, progressive splenomegaly, constitutional symptom, thromboses or accelerated/blastic phase disease. Treatment strategies are variable and there are no widely accepted consensus management guidelines for MNU-U. Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative strategy yet outcomes, to date, are not well defined. We hereby report on the largest retrospective study of patients with MPN-U undergoing allo-HCT, highlighting the potentially curative role and providing clinicians with robust engraftment, GvHD and outcome data to facilitate patient discussion.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
437-441Informations de copyright
© 2020 British Society for Haematology and John Wiley & Sons Ltd.
Références
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