Bullous Pemphigoid in Which Eruption Developed Exclusively on Preexisting Eruption of Vitiligo Vulgaris.
Autoimmune regulator
Bullous pemphigoid
Macrophage migration inhibitory factor
Vitiligo vulgaris
Journal
Case reports in dermatology
ISSN: 1662-6567
Titre abrégé: Case Rep Dermatol
Pays: Switzerland
ID NLM: 101517685
Informations de publication
Date de publication:
Historique:
received:
08
11
2019
accepted:
08
01
2020
entrez:
29
2
2020
pubmed:
29
2
2020
medline:
29
2
2020
Statut:
epublish
Résumé
Coexistence of bullous pemphigoid (BP) and vitiligo vulgaris (VV) is very rare. We present a unique case of BP associated with VV in a 76-year-old Japanese man, in which BP eruption developed exclusively on preexisting VV regions. The patient was referred to us with a 3-month history of blistering eruption with severe pruritis on the right forearm and left lower limb. In addition, he had been suffering from a widespread depigmented eruption on the trunk and extremities for at least 20 years. Curiously, the blistering eruption developed exclusively on preexisting depigmented eruption. Histopathological and laboratory examinations identified the blistering eruption as BP. The depigmented eruption was diagnosed as VV. BP eruption responded quickly to oral prednisolone therapy, improving within 1 week, and the prednisolone dose was gradually tapered. Within 1 month, BP lesions almost completely resolved. In the present case, BP not only coexisted with VV, but also developed exclusively on preexisting vitiliginous regions. The present case strongly suggests that BP and VV are partly caused by common pathological mechanisms.
Identifiants
pubmed: 32110207
doi: 10.1159/000505829
pii: cde-0012-0033
pmc: PMC7036583
doi:
Types de publication
Case Reports
Langues
eng
Pagination
33-36Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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