Biological Reactions to Metal Particles and Ions in the Synovial Layer of Mice.
cytokines
inflammation
metal ions
metal particles
synovium
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
29
10
2019
revised:
21
02
2020
accepted:
24
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
1
3
2020
Statut:
epublish
Résumé
Metal particles and ions released from implants not only have a fundamental effect on the longevity of total joint replacements, but can also be disseminated to remote organs. Periprosthetic tissues harvested during revision surgeries mainly reflect end-stage failure but may not adequately reveal initial biological reactions and systemic side effects. Therefore, primary reactions caused by metal particles and ions were investigated in an established murine model. Left knee joints in three groups, each consisting of ten female BALB/c mice, received injections of metal ions (MI), metal particles (MP) and phosphate-buffered saline (PBS) (control). Seven days after the injection, immunohistochemical analyses of the synovial layer were performed with respect to some biological markers including Tumor necrosis factor -α (TNF-α), Interleukin-6 (IL-6), Interleukin-1β (IL-1β), Cluster of Differentiation 45 (CD45), Cluster of Differentiation 68 (CD68) and Cluster of Differentiation 3(CD3). The MP group showed significantly enhanced proinflammatory cytokine expression (TNF-α, IL-6 and IL-1β) compared with the other groups (p < 0.05). Interestingly, CD3, as a marker for T lymphocytes, did not increase in any of the groups. The MI group showed a significantly increased expression of CD45 compared with the control group (p < 0.05). Therefore, during the primary process, metal particles have stronger pro-inflammatory potential than metal ions, and T lymphocytes did not seem to be activated in our murine model. Systemic reactions caused by metal particles and ions were found by observing the untreated right knees.
Identifiants
pubmed: 32110869
pii: ma13051044
doi: 10.3390/ma13051044
pmc: PMC7084385
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : UT 119/3-1
Organisme : China Scholarship Council
ID : 201708140085
Références
Bone Joint J. 2016 Jul;98-B(7):925-33
pubmed: 27365470
Crit Rev Toxicol. 2018 Feb;48(2):170-193
pubmed: 29130357
J Biomed Mater Res A. 2010 Jun 15;93(4):1312-21
pubmed: 19844976
Biomaterials. 2012 Sep;33(27):6295-304
pubmed: 22704843
Int Orthop. 2018 Jan;42(1):65-70
pubmed: 28725970
Arch Immunol Ther Exp (Warsz). 2002;50(2):85-93
pubmed: 12022705
Wear. 2011 Jul 29;271(9-10):1658-1666
pubmed: 21804652
J Exp Med. 2005 May 2;201(9):1355-9
pubmed: 15867089
J Arthroplasty. 2004 Dec;19(8 Suppl 3):94-101
pubmed: 15578561
Bull NYU Hosp Jt Dis. 2009;67(2):182-8
pubmed: 19583551
J Long Term Eff Med Implants. 2014;24(4):283-96
pubmed: 25747031
J Biomed Mater Res B Appl Biomater. 2009 Nov;91(2):692-9
pubmed: 19572294
In Vivo. 2011 Jul-Aug;25(4):679-86
pubmed: 21709014
Acta Biomater. 2013 Sep;9(9):8046-58
pubmed: 23669623
Clin Cases Miner Bone Metab. 2013 Jan;10(1):34-40
pubmed: 23858309
J Mater Sci Mater Med. 2014 Feb;25(2):507-13
pubmed: 24249629
Nat Rev Rheumatol. 2013 Jan;9(1):5-6
pubmed: 23208186
J Mater Sci Mater Med. 2014 Jun;25(6):1599-612
pubmed: 24562818
J Appl Toxicol. 2015 Jun;35(6):614-22
pubmed: 25612073
J Clin Orthop Trauma. 2018 Jan-Mar;9(1):7-16
pubmed: 29628677
J Mater Sci Mater Med. 2014 Jan;25(1):141-9
pubmed: 24068541
Acta Biomater. 2009 Sep;5(7):2495-502
pubmed: 19375997
Nanomedicine. 2018 Apr;14(3):951-963
pubmed: 29339190
PLoS One. 2015 Mar 26;10(3):e0123155
pubmed: 25811996
Materials (Basel). 2019 Feb 05;12(3):
pubmed: 30764574
Int Orthop. 2014 Jun;38(6):1291-6
pubmed: 24652420
Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1:S1
pubmed: 22165815
J Bone Joint Surg Br. 2003 Jul;85(5):758-64
pubmed: 12892206
Life Sci. 2018 Jun 1;202:11-20
pubmed: 29577879
J Orthop Res. 2009 Jul;27(7):847-54
pubmed: 19105226
Br J Rheumatol. 1994 Apr;33(4):309-16
pubmed: 7512424
Lancet. 2012 Mar 31;379(9822):1199-204
pubmed: 22417410
J Biomed Mater Res B Appl Biomater. 2008 Feb;84(2):478-85
pubmed: 17879385
Clin Orthop Relat Res. 2010 Sep;468(9):2321-7
pubmed: 20458645
Biomaterials. 2007 Dec;28(34):5044-8
pubmed: 17645943
Acta Biomater. 2018 May;72:434-446
pubmed: 29649639
Acta Biomater. 2014 Jun;10(6):2354-66
pubmed: 24525037
Biomaterials. 2008 Sep;29(27):3738-42
pubmed: 18561997
Trends Immunol. 2006 Mar;27(3):146-53
pubmed: 16423560
Materials (Basel). 2017 Jul 03;10(7):
pubmed: 28773099
Cell Immunol. 2000 Jan 10;199(1):15-24
pubmed: 10675271
J Bone Joint Surg Br. 2003 Jan;85(1):133-41
pubmed: 12585592
Acta Biomater. 2014 Jan;10(1):1-10
pubmed: 24090989
Acta Biomater. 2013 Dec;9(12):9485-91
pubmed: 23933100
Virchows Arch. 2008 Nov;453(5):529-34
pubmed: 18769936
Clin Orthop Relat Res. 2007 Jul;460:240-52
pubmed: 17620815
Annu Rev Immunol. 2003;21:107-37
pubmed: 12414720
Acta Biomater. 2010 Nov;6(11):4296-304
pubmed: 20570640
J Biomed Mater Res A. 2003 Oct 1;67(1):312-27
pubmed: 14517891
J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1246-1253
pubmed: 30261124
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14833-8
pubmed: 8962141
J Arthroplasty. 2012 Mar;27(3):493.e13-7
pubmed: 21955792
J Bone Joint Surg Am. 2008 Nov;90 Suppl 4:202-8
pubmed: 18984732
Materials (Basel). 2019 Jan 28;12(3):
pubmed: 30696087
Front Immunol. 2018 Apr 25;9:831
pubmed: 29922277
Arthritis Res Ther. 2007;9 Suppl 1:S6
pubmed: 17634145
Int J Mol Sci. 2018 Nov 13;19(11):
pubmed: 30428596