The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases.
atherosclerosis
cardiovascular diseases
gut microbiota
microbiome
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
25
01
2020
revised:
19
02
2020
accepted:
21
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.
Identifiants
pubmed: 32110880
pii: nu12030605
doi: 10.3390/nu12030605
pmc: PMC7146472
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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