Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial.
de-intensification
head neck cancer
ipsilateral elective neck irradiation only
postoperative
radiotherapy
salivary glands
swallowing apparatus
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
15
01
2020
revised:
07
02
2020
accepted:
20
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
1
3
2020
Statut:
epublish
Résumé
Evaluating radiotherapy treatment plans of the prospective DIREKHT trial (ClinicalTrials.gov, NCT02528955) investigating de-intensification of radiotherapy in patients with head and neck cancer. The first 30 patients from the DIREKHT trial of the leading study centre were included in this analysis. Standard treatment plans and study treatment plans derived from the protocol were calculated for each patient. Sizes of planning target volumes (PTVs) and mean doses to organs at risk were compared using the Student's t-test with paired samples. Mean PTV3 including primary tumor region and ipsilateral elective neck up to a dose of 50 Gy in the study treatment plans was 662 mL (+/- 165 mL standard deviation (SD)) and therefore significantly smaller than those of the standard treatment plans (1166 mL (+/- 266 mL SD). In the medial and inferior constrictor muscles, cricopharyngeal muscle, glottic and supraglottic laryngeal areas, arytenoid cartilages, contralateral major salivary glands highly significant dose reductions ( De-intensification of radiotherapy led to smaller planning target volumes and clinical relevant dose reductions in the swallowing apparatus and in the contralateral salivary glands.
Identifiants
pubmed: 32110958
pii: cancers12030538
doi: 10.3390/cancers12030538
pmc: PMC7139715
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02528955']
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
On behalf of all authors the corresponding author states that there is no conflict of interest.
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