snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management.
lung cancer
rRNA chemical modification
ribosome
snoRNA
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
26 02 2020
26 02 2020
Historique:
received:
31
01
2020
revised:
21
02
2020
accepted:
24
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Small nucleolar RNAs (snoRNAs) are non-coding RNAs localized in the nucleolus, where they participate in the cleavage and chemical modification of ribosomal RNAs. Their biogenesis and molecular functions have been extensively studied since their identification in the 1960s. However, their role in cancer has only recently started to emerge. In lung cancer, efforts to profile snoRNA expression have enabled the definition of snoRNA-related signatures, not only in tissues but also in biological fluids, exposing these small RNAs as potential non-invasive biomarkers. Moreover, snoRNAs appear to be essential actors of lung cancer onset and dissemination. They affect diverse cellular functions, from regulation of the cell proliferation/death balance to promotion of cancer cell plasticity. snoRNAs display both oncogenic and tumor suppressive activities that are pivotal in lung cancer tumorigenesis and progression. Altogether, we review how further insight into snoRNAs may improve our understanding of basic lung cancer biology and the development of innovative diagnostic tools and therapies.
Identifiants
pubmed: 32111002
pii: cells9030541
doi: 10.3390/cells9030541
pmc: PMC7140444
pii:
doi:
Substances chimiques
RNA, Small Nucleolar
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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