Molecular Profiling of Keratinocyte Skin Tumors Links
Staphylococcus aureus
actinic keratosis
antimicrobial peptides
basal cell carcinoma
human β-defensin
skin microbiota
squamous cell carcinoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
08
11
2019
revised:
12
02
2020
accepted:
21
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
1
3
2020
Statut:
epublish
Résumé
The skin microbiota plays a prominent role in health and disease; however, its contribution to skin tumorigenesis is not well understood. We comparatively assessed the microbial community compositions from excision specimens of the main human non-melanoma skin cancers, actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Keratinocyte skin tumors are characterized by significantly different microbial community compositions, wherein AK and SCC are more similar to each other than to BCC. Notably, in SCC, which represents the advanced tumor entity and frequently develops from AK, overabundance of Staphylococcus aureus, a known skin pathogen, was noted. Moreover, S. aureus overabundance was significantly associated with increased human β-defensin-2 (hBD-2) expression in SCC. By challenging human SCC cell lines with
Identifiants
pubmed: 32111012
pii: cancers12030541
doi: 10.3390/cancers12030541
pmc: PMC7139500
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Austrian Science Fund
ID : FWF W1241-B18
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
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