miR-9 Does Not Regulate Lamin A Expression in Metastatic Cells from Lung Adenocarcinoma.
lamin A
lung adenocarcinoma
microRNA-9
pleural effusions
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
17
01
2020
revised:
20
02
2020
accepted:
22
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
In lung adenocarcinoma, low lamin A expression in pleural metastatic cells has been proposed as a pejorative factor. miR-9 physiologically inhibits the expression of lamin A in neural cells and seems to be a central actor in the carcinogenesis and the metastatic process in lung cancer. Thus, it could be a good candidate to explain the reduction of lamin A expression in lung adenocarcinoma cells. miR-9 expression was analyzed in 16 pleural effusions containing metastatic cells from lung adenocarcinoma and was significantly reduced in patients from the 'Low lamin A expression' group compared to patients from the 'High lamin A expression' group. Then, carcinoma cells selection by fluorescence-activated cell sorting (FACS) was performed according to epithelial membrane antigen (EMA) expression, reflecting lamin A expression. miR-9 was underexpressed in lamin A- carcinoma cells compared to lamin A+ carcinoma cells in patients from the 'Low lamin A expression' group, whereas there was no difference of miR-9 expression between lamin A+ and lamin A- carcinoma cells in patients from the 'High lamin A expression' group. These results suggest that miR-9 does not regulate lamin A expression in metastatic cells from lung adenocarcinoma. On the contrary, miR-9 expression was shown to be reduced in lamin A-negative carcinoma cells.
Identifiants
pubmed: 32111074
pii: ijms21051599
doi: 10.3390/ijms21051599
pmc: PMC7084260
pii:
doi:
Substances chimiques
Lamin Type A
0
MIRN92 microRNA, human
0
MicroRNAs
0
Mucin-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ARARD - Association Régionale d'Aide Respiratoire à Domicile) grant, Parc d'activités de Napollon, 100 avenue des Templiers, 13676 Aubagne Cedex, France
ID : ,
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