Autoantigen Treatment in Type 1 Diabetes: Unsolved Questions on How to Select Autoantigen and Administration Route.
Administration, Oral
Animals
Autoantigens
/ administration & dosage
Chemotherapy, Adjuvant
Diabetes Mellitus, Type 1
/ drug therapy
Drug Therapy, Combination
Glutamate Decarboxylase
/ therapeutic use
Humans
Injections, Intralymphatic
Injections, Subcutaneous
Insulin
/ metabolism
Proinsulin
/ therapeutic use
Vitamin D
/ therapeutic use
GAD-alum
autoantigen treatment
combination therapy
intralymphatic treatment
oral administration
type 1 diabetes
vitamin D
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
29
01
2020
revised:
19
02
2020
accepted:
21
02
2020
entrez:
1
3
2020
pubmed:
1
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease. In experimental animal models, efficacy was good, but was insufficient in human subjects. Besides the possible minor efficacy of peroral insulin in high-risk individuals to prevent T1D, autoantigen prevention trials have failed. Other studies on autoantigen prevention and intervention at diagnosis are ongoing. One problem is to select autoantigen/s; others are dose and route. Oral administration may be improved by using different vehicles. Proinsulin peptide therapy in patients with T1D has shown possible minor efficacy. In patients with newly diagnosed T1D, subcutaneous injection of glutamic acid decarboxylase (GAD) bound to alum hydroxide (GAD-alum) can likely preserve beta-cell function, but the therapeutic effect needs to be improved. Intra-lymphatic administration may be a better alternative than subcutaneous administration, and combination therapy might improve efficacy. This review elucidates some actual problems of autoantigen therapy in the prevention and/or early intervention of type 1 diabetes.
Identifiants
pubmed: 32111075
pii: ijms21051598
doi: 10.3390/ijms21051598
pmc: PMC7084272
pii:
doi:
Substances chimiques
Autoantigens
0
Insulin
0
Vitamin D
1406-16-2
Proinsulin
9035-68-1
Glutamate Decarboxylase
EC 4.1.1.15
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Barndiabetesfonden ( the Swedish Child Diabetes Foundation)
ID : 0000
Organisme : Diabetesfonden ( The Swedish Diabetes Association)
ID : 0000
Organisme : FORSS ( Research Council of Southeast Sweden
ID : 0000
Organisme : Juvenile Diabetes Research Foundation International
ID : 0000
Organisme : Medicinska Forskningsrådet
ID : 0000
Références
N Engl J Med. 2015 Feb 26;372(9):880-1
pubmed: 25714168
Diabetes Care. 2004 Oct;27(10):2348-55
pubmed: 15451899
N Engl J Med. 2019 Aug 15;381(7):603-613
pubmed: 31180194
Adv Drug Deliv Rev. 2013 Jun 15;65(6):782-99
pubmed: 23099275
Nat Immunol. 2010 Mar;11(3):225-31
pubmed: 20139986
Nat Biotechnol. 1998 Oct;16(10):934-8
pubmed: 9788349
Diabetologia. 2007 Mar;50(3):503-9
pubmed: 17235526
N Engl J Med. 1993 Sep 30;329(14):977-86
pubmed: 8366922
Front Immunol. 2018 Jan 17;8:1961
pubmed: 29387056
J Immunol. 2007 Jan 1;178(1):145-53
pubmed: 17182549
Nature. 1982 Jul 8;298(5870):167-9
pubmed: 7045690
Nat Rev Endocrinol. 2019 Nov;15(11):623-624
pubmed: 31471596
Lancet Diabetes Endocrinol. 2019 Jan;7(1):65-74
pubmed: 30528100
Diabetes Res. 1991 Mar;16(3):145-8
pubmed: 1666347
N Engl J Med. 2017 Feb 16;376(7):697-699
pubmed: 28199812
J Diabetes Complications. 2005 Jul-Aug;19(4):238-46
pubmed: 15993359
Diabetes. 2013 Nov;62(11):3901-8
pubmed: 23801579
Neurology. 2011 Oct 18;77(16):1551-60
pubmed: 21975206
BMC Public Health. 2015 Mar 17;15:255
pubmed: 25849566
J Clin Invest. 2015 Jan;125(1):448-55
pubmed: 25500887
Diabetes Care. 2005 May;28(5):1068-76
pubmed: 15855569
J Allergy Clin Immunol. 2013 Feb;131(2):412-20
pubmed: 23374268
Science. 2016 Feb 12;351(6274):711-4
pubmed: 26912858
J Allergy Clin Immunol. 2012 May;129(5):1290-6
pubmed: 22464647
Diabetes. 2020 Feb;69(2):215-227
pubmed: 31712320
Curr Diab Rep. 2013 Dec;13(6):795-804
pubmed: 24072479
Arch Dis Child. 2008 Jun;93(6):512-7
pubmed: 18339654
Diabetologia. 2000 Aug;43(8):1000-4
pubmed: 10990077
Lancet. 2011 Jul 23;378(9788):319-27
pubmed: 21714999
Annu Rev Immunol. 2006;24:571-606
pubmed: 16551260
Nat Commun. 2019 May 14;10(1):2150
pubmed: 31089130
Diabetes Care. 2019 Apr;42(4):553-559
pubmed: 30692241
J Clin Invest. 2012 May;122(5):1717-25
pubmed: 22484814
Scand J Immunol. 2006 Jan;63(1):59-69
pubmed: 16398702
PLoS One. 2015 Jun 03;10(6):e0127057
pubmed: 26039878
Curr Diab Rep. 2008 Apr;8(2):87-93
pubmed: 18445349
Diabetologia. 2017 Aug;60(8):1467-1474
pubmed: 28526919
Cell. 1989 Oct 20;59(2):247-55
pubmed: 2478291
JAMA Neurol. 2013 Sep 1;70(9):1105-9
pubmed: 23817921
Nat Rev Endocrinol. 2015 May;11(5):289-97
pubmed: 25688000
Diabetes Metab Res Rev. 2014 Jul;30(5):405-14
pubmed: 24302596
Nat Med. 2000 Oct;6(10):1167-75
pubmed: 11017150
Br Med J (Clin Res Ed). 1983 Jan 15;286(6360):176-8
pubmed: 6401518
Immunotherapy. 2017 Jun;9(8):619-621
pubmed: 28653568
Clin Immunol. 2008 Jun;127(3):359-65
pubmed: 18358785
Arthritis Rheum. 2009 Nov;60(11):3207-16
pubmed: 19877047
Curr Diab Rep. 2013 Oct;13(5):616-23
pubmed: 23888323
Hum Vaccin. 2011 Jan 1;7(1):19-26
pubmed: 21157185
Lancet Gastroenterol Hepatol. 2017 Jul;2(7):479-493
pubmed: 28506538
Lancet Diabetes Endocrinol. 2019 Jan;7(1):52-64
pubmed: 30528099
J Immunol. 1999 Aug 1;163(3):1178-87
pubmed: 10415012
Eur J Immunol. 2005 Jun;35(6):1869-76
pubmed: 15909311
Islets. 2013 Mar-Apr;5(2):53-66
pubmed: 23648893
Immunol Lett. 2014 May-Jun;159(1-2):30-5
pubmed: 24576850
Nature. 1993 Nov 4;366(6450):69-72
pubmed: 7694152
Immunity. 2005 Aug;23(2):115-26
pubmed: 16111631
Cell. 2019 May 30;177(6):1583-1599.e16
pubmed: 31150624
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11465-9
pubmed: 1722335
Diabetes Care. 2010 Sep;33(9):1962-3
pubmed: 20805274
J Immunol. 2000 Mar 1;164(5):2405-11
pubmed: 10679076
Diabetes. 2010 Nov;59(11):2846-53
pubmed: 20699420
Curr Med Chem. 2011;18(4):577-86
pubmed: 21143110
Lancet. 2000 Aug 12;356(9229):545-9
pubmed: 10950231
N Engl J Med. 1983 May 19;308(20):1226-7
pubmed: 6341839
Lancet. 2016 Jun 4;387(10035):2340-2348
pubmed: 27302273
Clin Exp Immunol. 2007 Apr;148(1):17-31
pubmed: 17349010
JAMA. 2015 Apr 21;313(15):1541-9
pubmed: 25898052
N Engl J Med. 2008 Oct 30;359(18):1909-20
pubmed: 18843118
J Clin Invest. 2015 Jan;125(1):94-6
pubmed: 25500880
Int Arch Allergy Immunol. 2009;150(1):59-65
pubmed: 19339803
J Immunol. 2001 Nov 1;167(9):4974-80
pubmed: 11673504
Diabetologia. 2009 Jan;52(1):175-6
pubmed: 19005640
Ann Neurol. 2008 May;63(5):611-20
pubmed: 18481290
Diabetes Care. 2003 Mar;26(3):832-6
pubmed: 12610045
Arch Neurol. 2007 Oct;64(10):1407-15
pubmed: 17698695
Mol Metab. 2016 Feb 22;5(4):255-262
pubmed: 27069865
N Engl J Med. 2002 May 30;346(22):1685-91
pubmed: 12037147
J Immunol. 2001 Mar 1;166(5):2982-91
pubmed: 11207247
J Autoimmun. 2014 May;50:38-41
pubmed: 24239002
J Immunol. 2006 Apr 15;176(8):4608-15
pubmed: 16585551
J Gen Physiol. 2004 Mar;123(3):185-90
pubmed: 14769848
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6800-5
pubmed: 11371626
Br Med J. 1979 Nov 17;2(6200):1257-9
pubmed: 117878
BMJ Open. 2019 Jun 28;9(6):e028578
pubmed: 31256036
Lancet. 2018 Aug 11;392(10146):477-486
pubmed: 30129464
Diabetes Care. 2008 Oct;31(10):1966-71
pubmed: 18628574
Eur J Neurol. 2006 Aug;13(8):887-95
pubmed: 16879301
Eur J Immunol. 2005 Feb;35(2):568-74
pubmed: 15682446
Ann Neurol. 2010 Nov;68(5):593-601
pubmed: 21031576
N Engl J Med. 2012 Feb 2;366(5):433-42
pubmed: 22296077
JAMA. 2017 Nov 21;318(19):1891-1902
pubmed: 29164254
World J Diabetes. 2019 Dec 15;10(12):560-580
pubmed: 31915518
Immunol Today. 1996 Jul;17(7):312-7
pubmed: 8763816
Diabetes Care. 2009 Jul;32(7):1244-9
pubmed: 19366957
Front Immunol. 2018 Feb 28;9:392
pubmed: 29541078
Nature. 1993 Nov 4;366(6450):72-5
pubmed: 8232539
N Engl J Med. 2009 Nov 26;361(22):2143-52
pubmed: 19940299
Diabetes. 2019 May;68(5):879-886
pubmed: 31010879
Diabetologia. 2011 Mar;54(3):634-40
pubmed: 21116604
Diabetes Metab Res Rev. 2019 May;35(4):e3132
pubmed: 30693639
Front Immunol. 2019 May 14;10:967
pubmed: 31139178
N Engl J Med. 2002 May 30;346(22):1692-8
pubmed: 12037148
N Engl J Med. 2005 Jun 23;352(25):2598-608
pubmed: 15972866
Lancet. 2011 Aug 6;378(9790):487-97
pubmed: 21719095
N Engl J Med. 2017 Jul 27;377(4):403-5
pubmed: 28745988
Lancet. 2016 Jun 4;387(10035):2331-2339
pubmed: 27302272
Diabetes. 2014 Sep;63(9):3128-34
pubmed: 25146474
J Immunother. 2005 Sep-Oct;28(5):438-48
pubmed: 16113600
Diabetes. 2009 Dec;58(12):2835-42
pubmed: 19755526
Lancet. 2008 Nov 15;372(9651):1746-55
pubmed: 18814906
Immunity. 1999 Oct;11(4):463-72
pubmed: 10549628
Nat Med. 2000 Oct;6(10):1176-82
pubmed: 11017151
Diabetes Care. 2010 Jul;33(7):1443-8
pubmed: 20357369
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17908-12
pubmed: 19001265
N Engl J Med. 2019 Nov 7;381(19):1879-1880
pubmed: 31693817
J Autoimmun. 1995 Dec;8(6):787-807
pubmed: 8824707
Sci Transl Med. 2017 Aug 9;9(402):
pubmed: 28794283
Diabetes. 2014 Aug;63(8):2876-87
pubmed: 24677716
Diabetologia. 2005 Jul;48(7):1247-57
pubmed: 15971062
Diabetologia. 2017 Jan;60(1):43-49
pubmed: 27704166
Benef Microbes. 2015;6(4):591-601
pubmed: 25576592
Immunology. 2013 Mar;138(3):269-79
pubmed: 23228173
J Immunol. 2000 May 1;164(9):4443-51
pubmed: 10779743
Diabetes. 2010 Sep;59(9):2087-93
pubmed: 20805382
Front Cell Dev Biol. 2015 Oct 27;3:67
pubmed: 26579520
Nutr Res Rev. 2009 Jun;22(1):82-92
pubmed: 19555519
J Clin Invest. 2015 Aug 3;125(8):3285-96
pubmed: 26193635
Nat Rev Rheumatol. 2017 Sep;13(9):525-537
pubmed: 28701761
Clin Exp Immunol. 2009 Feb;155(2):156-65
pubmed: 19040615
Nat Med. 1996 Dec;2(12):1348-53
pubmed: 8946834
Diabetes Care. 2015 Oct;38(10):1964-74
pubmed: 26404926
Diabetes. 2014 Sep;63(9):3033-40
pubmed: 24705406
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3299-303
pubmed: 11248073
Vaccine. 2014 Apr 25;32(20):2300-7
pubmed: 24631074
Diabetologia. 2017 Jul;60(7):1276-1283
pubmed: 28357504
Am J Epidemiol. 2013 Mar 1;177(5):411-9
pubmed: 23380046
Diabetes Care. 2009 Nov;32(11):2036-40
pubmed: 19690081
Lancet. 2001 Nov 3;358(9292):1500-3
pubmed: 11705562
N Engl J Med. 1994 Jan 6;330(1):15-8
pubmed: 8259139
EBioMedicine. 2017 Dec;26:78-90
pubmed: 29191561