Bile acid composition regulates GPR119-dependent intestinal lipid sensing and food intake regulation in mice.
appetite
bile acid
gastric emptying
obesity
small intestine
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
21
08
2019
revised:
21
01
2020
accepted:
06
02
2020
pubmed:
1
3
2020
medline:
7
4
2021
entrez:
1
3
2020
Statut:
ppublish
Résumé
Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or eliminating BAs strongly impacts GI functions. We used a mouse model (Cyp8b1 We evaluated OEA levels, gastric emptying and food intake in wild-type and Cyp8b1 Cyp8b1 BAs regulate gastric emptying and satiation by determining fat-dependent GPR119 activity in distal intestine.
Identifiants
pubmed: 32111630
pii: gutjnl-2019-319693
doi: 10.1136/gutjnl-2019-319693
pmc: PMC7423635
mid: NIHMS1558797
doi:
Substances chimiques
Bile Acids and Salts
0
Dietary Fats
0
Gpr119 protein, mouse
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1620-1628Subventions
Organisme : NIDA NIH HHS
ID : R00 DA034009
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115825
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA034009
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK119498
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007328
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119498
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK026687
Pays : United States
Organisme : NIDDK NIH HHS
ID : L30 DK114978
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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