Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence.
Crohn's disease
energy metabolism
inflammatory bowel disease
intestinal epithelium
intestinal stem cell
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
20
07
2019
revised:
23
01
2020
accepted:
03
02
2020
pubmed:
1
3
2020
medline:
17
4
2021
entrez:
1
3
2020
Statut:
ppublish
Résumé
Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn's disease (CD). PCs reside in proximity to Lgr5 Ileal tissue samples from patients with CD, mouse models for mitochondrial dysfunction (Hsp60 In patients with CD and TNF We provide evidence that inflammation-associated mitochondrial dysfunction in the intestinal epithelium triggers a metabolic imbalance, causing reduced stemness and acquisition of a dysfunctional PC phenotype. Blocking glycolysis might be a novel drug target to antagonise PC dysfunction in the pathogenesis of CD.
Identifiants
pubmed: 32111634
pii: gutjnl-2019-319514
doi: 10.1136/gutjnl-2019-319514
pmc: PMC7569388
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1939-1951Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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