Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation.

Animals Anti-Inflammatory Agents / chemistry Arachidonate 5-Lipoxygenase / metabolism Cell Line Humans Inflammation / drug therapy Lipoxygenase Inhibitors / chemistry Male Mice, Inbred BALB C Oryza / chemistry Proanthocyanidins / chemistry Psoriasis / drug therapy Rats
Anti-inflammation Arachidonate 5-lipoxygenase Leukotriene B(4) Psoriasis Red-kerneled rice proanthocyanidin

Journal

Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430

Informations de publication

Date de publication:
15 08 2020
Historique:
received: 21 09 2019
revised: 14 02 2020
accepted: 18 02 2020
pubmed: 1 3 2020
medline: 10 10 2020
entrez: 1 3 2020
Statut: ppublish

Résumé

5-lipoxygenase is a key enzyme in the synthesis of leukotrienes from arachidonic acid. The produced leukotrienes are involved in inflammatory diseases including psoriasis, asthma, and atherosclerosis. A suitable 5-lipoxygenase inhibitor might be useful for preventing and improving the symptoms of leukotriene-related inflammatory diseases. Here, we investigate the mechanism underlying the anti-inflammatory effect of a proanthocyanidin found in red-kerneled rice. Red-kerneled rice proanthocyanidin exhibited potent mixed noncompetitive inhibition of human and rat 5-lipoxygenases, with an IC

Identifiants

DOI: 10.1016/j.abb.2020.108307 PMID: 32112739
pubmed: 32112739
pii: S0003-9861(19)30833-1
doi: 10.1016/j.abb.2020.108307
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Lipoxygenase Inhibitors 0
Proanthocyanidins 0
proanthocyanidin 18206-61-6
Arachidonate 5-Lipoxygenase EC 1.13.11.34

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108307

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Keisuke Toda (K)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Izumi Tsukayama (I)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yuki Nagasaki (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yuka Konoike (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan; Department of Nutrition and Life Science, Fukuyama University, Sanzo, Gakuen-cho 1, Fukuyama, Hiroshima, 729-0292, Japan.

Asako Tamenobu (A)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Natsuki Ganeko (N)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Hideyuki Ito (H)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yuki Kawakami (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yoshitaka Takahashi (Y)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan.

Yoshimi Miki (Y)

Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Kei Yamamoto (K)

Graduate School of Technology, Industrial and Social Science, Tokushima University, 2-1, Minami-jyosanjima-cho, Tokushima, 770-8513, Japan.

Makoto Murakami (M)

Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Toshiko Suzuki-Yamamoto (T)

Department of Nutritional Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama, 719-1197, Japan. Electronic address: toshiko@fhw.oka-pu.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 5-lipoxygenase › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la lipoxygénase › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Poaceae › Oryza › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Structures macromoléculaires › Tanins › Proanthocyanidines › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Red-kerneled rice proanthocyanidin inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Red-kerneled rice proanthocyanidin inhibits...