Signal regulators of human naïve pluripotency.
Human pluripotent stem cells
Naïve pluripotency
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
08
08
2019
revised:
18
02
2020
accepted:
23
02
2020
pubmed:
1
3
2020
medline:
11
11
2020
entrez:
1
3
2020
Statut:
ppublish
Résumé
Pluripotent cells transiently develop during peri-implantation embryogenesis and have the capacity to convert into three embryonic lineages. Two typical states of pluripotency, naïve and primed, can be experimentally induced in vitro. The in vitro naïve state can be stabilized in response to environmental inductive cues via a unique transcriptional regulatory program. However, interference with various signaling pathways creates a spectrum of alternative pluripotent cells that display different functions and molecular expression patterns. Similarly, human naïve pluripotent cells can be placed into two main levels - intermediate and bona fide. Here, we discuss several culture conditions that have been used to establish naïve-associated gene regulatory networks in human pluripotent cells. We also describe different transcriptional patterns in various culture systems that are associated with these two levels of human naïve pluripotency.
Identifiants
pubmed: 32112799
pii: S0014-4827(20)30129-4
doi: 10.1016/j.yexcr.2020.111924
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111924Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.