Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses.

Animals Carbon Tetrachloride / toxicity Chemical and Drug Induced Liver Injury / genetics Hepatocytes / pathology Liver / pathology Liver Cirrhosis / chemically induced Mice NF-E2-Related Factor 2 / genetics
Inflammatory response Liver fibrosis MCP-1 Nrf2 Oxidative damage

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
04 2020
Historique:
received: 19 12 2019
revised: 10 02 2020
accepted: 19 02 2020
pubmed: 1 3 2020
medline: 22 6 2021
entrez: 1 3 2020
Statut: ppublish

Résumé

Liver fibrosis, in which hepatocyte damage and inflammatory response play critical roles, is a physiological response to chronic or iterative liver injury and can progress to cirrhosis over time. Nuclear factor E2-related factor 2 (Nrf2) is a master transcription factor that regulates oxidative and xenobiotic stress responses as well as inflammation. To ascertain the cell-specific roles of Nrf2 in hepatocytes and myeloid lineage cells in the progression of liver fibrosis, mice lacking Nrf2 specifically in hepatocytes [Nrf2(L)-KO] and myeloid lineage cells [Nrf2(M)-KO] were generated to evaluate carbon tetrachloride (CCl Nrf2-mediated antioxidant response in the liver is responsive to acute CCl Deficiency of Nrf2 in hepatocytes sensitizes the cells to CCl

Sections du résumé

BACKGROUND
Liver fibrosis, in which hepatocyte damage and inflammatory response play critical roles, is a physiological response to chronic or iterative liver injury and can progress to cirrhosis over time. Nuclear factor E2-related factor 2 (Nrf2) is a master transcription factor that regulates oxidative and xenobiotic stress responses as well as inflammation.
METHOD
To ascertain the cell-specific roles of Nrf2 in hepatocytes and myeloid lineage cells in the progression of liver fibrosis, mice lacking Nrf2 specifically in hepatocytes [Nrf2(L)-KO] and myeloid lineage cells [Nrf2(M)-KO] were generated to evaluate carbon tetrachloride (CCl
RESULTS
Nrf2-mediated antioxidant response in the liver is responsive to acute CCl
CONCLUSION
Deficiency of Nrf2 in hepatocytes sensitizes the cells to CCl

Identifiants

DOI: 10.1016/j.freeradbiomed.2020.02.015 PMID: 32112813
pubmed: 32112813
pii: S0891-5849(19)32548-1
doi: 10.1016/j.freeradbiomed.2020.02.015
pii:
doi:

Substances chimiques

NF-E2-Related Factor 2 0
Carbon Tetrachloride CL2T97X0V0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

136-147

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no conflict of interest.

Auteurs

Hang Lyu (H)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Huihui Wang (H)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Lu Li (L)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Jiayu Zhu (J)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Feng Chen (F)

Department of Interventional Radiology, The First Affiliated Hospital of Shandong First Medical University, No. 16766 Jingshi Road, Lixia Area, Jinan, 250014, China.

Yannan Chen (Y)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Cuijie Liu (C)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Jingqi Fu (J)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Bei Yang (B)

Department of Histology and Embryology, College of Basic Medical Science, China Medical University, China.

Qiang Zhang (Q)

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.

Yuanyuan Xu (Y)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: yyxu@cmu.edu.cn.

Jingbo Pi (J)

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China. Electronic address: jbpi@cmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures chlorés › Tétrachloro-méthane › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › Système digestif › Foie › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Cirrhose du foie › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hepatocyte-specific deficiency of Nrf2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Hepatocyte-specific deficiency of Nrf2...