Aged
Coronary Artery Disease
/ complications
Cross-Sectional Studies
Female
Fluorodeoxyglucose F18
HIV Infections
/ complications
Humans
Male
Middle Aged
Positron Emission Tomography Computed Tomography
Predictive Value of Tests
Radiopharmaceuticals
Reproducibility of Results
Risk Assessment
Risk Factors
Sodium Fluoride
Coronary atherosclerosis
Fluorodeoxyglucose
Human immunodeficiency virus
Molecular imaging
Sodium fluoride
Journal
Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
05
12
2019
revised:
18
01
2020
accepted:
14
02
2020
pubmed:
1
3
2020
medline:
7
4
2021
entrez:
1
3
2020
Statut:
ppublish
Résumé
Molecular imaging with We performed FDG and NaF PET/CT imaging in two clinically similar cohorts of patients living with HIV (PLWH) with no symptomatic cardiovascular disease. The prevalence and intensity of coronary artery uptake of each tracer, measured as target-to-background ratio (TBR), were assessed in patients at low and high cardiovascular risk. Ninety-three PLWH were submitted to PET/CT imaging with FDG (N = 43) and NaF (N = 50); 42% were at low and 58% at high cardiovascular risk. The intensity of uptake and multivessel coronary artery uptake were significantly higher with NaF than FDG both in low and high-risk patients. When each The prevalence of coronary artery uptake was higher with NaF compared to FDG both in high and low risk patients, hence microcalcification imaging may be a more sensitive tool to detect coronary atherosclerosis than inflammation imaging. However, the uptake of each
Sections du résumé
BACKGROUND AND AIMS
Molecular imaging with
METHODS
We performed FDG and NaF PET/CT imaging in two clinically similar cohorts of patients living with HIV (PLWH) with no symptomatic cardiovascular disease. The prevalence and intensity of coronary artery uptake of each tracer, measured as target-to-background ratio (TBR), were assessed in patients at low and high cardiovascular risk.
RESULTS
Ninety-three PLWH were submitted to PET/CT imaging with FDG (N = 43) and NaF (N = 50); 42% were at low and 58% at high cardiovascular risk. The intensity of uptake and multivessel coronary artery uptake were significantly higher with NaF than FDG both in low and high-risk patients. When each
CONCLUSIONS
The prevalence of coronary artery uptake was higher with NaF compared to FDG both in high and low risk patients, hence microcalcification imaging may be a more sensitive tool to detect coronary atherosclerosis than inflammation imaging. However, the uptake of each
Identifiants
pubmed: 32113050
pii: S0021-9150(20)30094-0
doi: 10.1016/j.atherosclerosis.2020.02.014
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Sodium Fluoride
8ZYQ1474W7
Types de publication
Comparative Study
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-135Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declared they do not have anything to disclose regarding conflict of interest with respect to this manuscript.