Anti-inflammatory sesquiterpenoids from the leaves of Datura metel L.
Anti-inflammatory activity
Datura metel L
Eudesmane-type
Sesquiterpenoids
Solanaceae
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
14
01
2020
revised:
22
02
2020
accepted:
23
02
2020
pubmed:
3
3
2020
medline:
19
12
2020
entrez:
2
3
2020
Statut:
ppublish
Résumé
Nine new (1-9) and three known (10-12) sesquiterpenoids were isolated from the ethanol-water (7:3, v/v) extract of the Datura metel L. leaves. The structures of 1-9 were elucidated by detailed spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS. All isolates (1-12) were evaluated for anti-inflammatory activity against the production of nitrogen oxide in lipopolysaccharide-induced RAW264.7 cells and compound 5 possessed the best inhibitory effect among them, with the IC
Identifiants
pubmed: 32114039
pii: S0367-326X(20)30113-1
doi: 10.1016/j.fitote.2020.104531
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104531Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.