Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish.

Animals Contraceptive Agents, Hormonal / toxicity Eye / drug effects Female Male Medroxyprogesterone Acetate / toxicity Receptors, Notch / metabolism Retina Signal Transduction / drug effects Transcription, Genetic / drug effects Zebrafish / genetics
Eye Medroxyprogesterone acetate Notch signaling pathway Visual cycle Zebrafish

Journal

Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381

Informations de publication

Date de publication:
15 Apr 2020
Historique:
received: 14 10 2019
revised: 20 02 2020
accepted: 21 02 2020
pubmed: 3 3 2020
medline: 30 5 2020
entrez: 2 3 2020
Statut: ppublish

Résumé

Medroxyprogesterone acetate (MPA) is a widely used synthetic progestin in contraception pills and hormone replacement therapy. However, its effects on eye growth and development and function were largely unknown. In this study, the transcription of genes in the Notch signaling pathway and the visual cycle network were evaluated after chronic MPA exposure at 4.32 (L), 42.0 (M), and 424 (H) ng L

Identifiants

DOI: 10.1016/j.ecoenv.2020.110371 PMID: 32114246
pubmed: 32114246
pii: S0147-6513(20)30210-4
doi: 10.1016/j.ecoenv.2020.110371
pii:
doi:

Substances chimiques

Contraceptive Agents, Hormonal 0
Receptors, Notch 0
Medroxyprogesterone Acetate C2QI4IOI2G

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110371

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Wen-Jun Shi (WJ)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China; State Key Laboratory of Organic Geochemistry, CAS Research Centre for Pearl River Delta Environment Pollution and Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Guo-Yong Huang (GY)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.

Yu-Xia Jiang (YX)

State Key Laboratory of Organic Geochemistry, CAS Research Centre for Pearl River Delta Environment Pollution and Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Dong-Dong Ma (DD)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.

Hong-Xing Chen (HX)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.

Ming-Zhi Huang (MZ)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China.

Ling-Ping Hou (LP)

School of Life Sciences, Guangzhou University, Guangzhou, 510655, China.

Lingtian Xie (L)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address: lingtian.xie@m.scnu.edu.cn.

Guang-Guo Ying (GG)

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address: guangguo.ying@m.scnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs de la reproduction › Contraceptifs › Contraceptifs hormonaux › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Organes des sens › Oeil › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Prégnanes › Prégnènes › Prégnènediones › Médroxyprogestérone › Acétate de médroxyprogestérone › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Medroxyprogesterone acetate affects eye growth...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Medroxyprogesterone acetate affects eye growth...