Focal alterations of the callosal area III in primary lateral sclerosis: An MRI planimetry and texture analysis.
Adult
Aged
Aged, 80 and over
Amyotrophic Lateral Sclerosis
/ diagnostic imaging
Atrophy
/ diagnostic imaging
Corpus Callosum
/ diagnostic imaging
Diffusion Tensor Imaging
/ methods
Female
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Motor Neuron Disease
/ diagnostic imaging
White Matter
/ diagnostic imaging
Amyotrophic lateral sclerosis
Corpus callosum
Magnetic resonance imaging
Motor neuron disease
Primary lateral sclerosis
Texture analysis
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
11
2019
revised:
18
02
2020
accepted:
19
02
2020
pubmed:
3
3
2020
medline:
23
2
2021
entrez:
2
3
2020
Statut:
ppublish
Résumé
The regional distribution of cerebral morphological alterations in primary lateral sclerosis (PLS) is considered to include the area III of the corpus callosum (CC). The study was designed to investigate regional white matter (WM) alterations in the callosal area III by T1 weighted magnetic resonance imaging (T1w-MRI) data in PLS patients compared with healthy controls, in order to identify atrophy and texture changes in vivo. T1w-MRI-based white matter mapping was used to perform an operator-independent CC-segmentation for the different areas of the CC in 67 PLS patients vs 82 matched healthy controls and vs 85 ALS patients. The segmentation was followed by texture analysis of the separated CC areas for the PLS patients vs controls and vs ALS patients. PLS was associated with significant atrophy in the area III of the CC (but not in the other callosal segments), while the alterations in the ALS patients were much more variable and were not significant at the group level. Furthermore, significant regional alterations of the texture parameters entropy and homogeneity in this area were shown in PLS patients and in ALS patients. This T1w-MRI study demonstrated focused regional CC atrophy and texture alterations limited to the callosal area III (which comprises fibers projecting into the primary motor cortices) in PLS, in comparison to a higher variability in CC size in ALS.
Sections du résumé
BACKGROUND
The regional distribution of cerebral morphological alterations in primary lateral sclerosis (PLS) is considered to include the area III of the corpus callosum (CC).
OBJECTIVE
The study was designed to investigate regional white matter (WM) alterations in the callosal area III by T1 weighted magnetic resonance imaging (T1w-MRI) data in PLS patients compared with healthy controls, in order to identify atrophy and texture changes in vivo.
METHODS
T1w-MRI-based white matter mapping was used to perform an operator-independent CC-segmentation for the different areas of the CC in 67 PLS patients vs 82 matched healthy controls and vs 85 ALS patients. The segmentation was followed by texture analysis of the separated CC areas for the PLS patients vs controls and vs ALS patients.
RESULTS
PLS was associated with significant atrophy in the area III of the CC (but not in the other callosal segments), while the alterations in the ALS patients were much more variable and were not significant at the group level. Furthermore, significant regional alterations of the texture parameters entropy and homogeneity in this area were shown in PLS patients and in ALS patients.
CONCLUSIONS
This T1w-MRI study demonstrated focused regional CC atrophy and texture alterations limited to the callosal area III (which comprises fibers projecting into the primary motor cortices) in PLS, in comparison to a higher variability in CC size in ALS.
Identifiants
pubmed: 32114375
pii: S2213-1582(20)30060-7
doi: 10.1016/j.nicl.2020.102223
pmc: PMC7049663
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102223Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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