Percutaneous coronary intervention versus medical therapy in patients with angina and grey-zone fractional flow reserve values: a randomised clinical trial.
Angina, Stable
/ diagnosis
Cardiovascular Agents
/ therapeutic use
Coronary Angiography
/ methods
Coronary Vessels
/ diagnostic imaging
Echocardiography, Doppler, Color
/ methods
Female
Fractional Flow Reserve, Myocardial
/ physiology
Humans
Magnetic Resonance Imaging, Cine
/ methods
Male
Middle Aged
Myocardial Perfusion Imaging
/ methods
Outcome Assessment, Health Care
Percutaneous Coronary Intervention
/ adverse effects
Symptom Assessment
/ methods
combined pressure and doppler flow coronary wire
fractional flow reserve
percutaneous coronary intervention
stress perfusion MRI
Journal
Heart (British Cardiac Society)
ISSN: 1468-201X
Titre abrégé: Heart
Pays: England
ID NLM: 9602087
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
08
10
2019
revised:
27
12
2019
accepted:
03
01
2020
pubmed:
3
3
2020
medline:
18
2
2021
entrez:
2
3
2020
Statut:
ppublish
Résumé
There is conflicting evidence regarding the benefits of percutaneous coronary intervention (PCI) in patients with grey zone fractional flow reserve ( We enrolled 104 patients with angina with 1:1 randomisation to PCI or OMT. The artery was interrogated with a Doppler flow/pressure wire. Patients underwent Magnetic Resonance Imaging (MRI) with follow-up at 3 and 12 months. The primary outcome was angina status at 3 months using the Seattle Angina Questionnaire (SAQ). 104 patients (age 60±9 years), 79 (76%) males and 79 (76%) Left Anterior Descending (LAD) stenoses were randomised. Coronary physiology and SAQ were similar. Of 98 patients with stress perfusion MRI data, 17 (17%) had abnormal perfusion (≥2 segments with ≥25% ischaemia or ≥1 segment with ≥50% ischaemia) in the target Non-invasive evidence of major ischaemia is uncommon in patients with NCT02425969.
Identifiants
pubmed: 32114516
pii: heartjnl-2019-316075
doi: 10.1136/heartjnl-2019-316075
pmc: PMC7229900
doi:
Substances chimiques
Cardiovascular Agents
0
Banques de données
ClinicalTrials.gov
['NCT02425969']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
758-764Subventions
Organisme : British Heart Foundation
ID : PG/14/97/31263
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/186134217
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: There was no industry sponsorship of this trial. CB has undertaken research, consulting and lectures for Abbott Vascular, Opsens and Coroventis based on contracts with The University of Glasgow. KGO has received speaker fees from Abbott Vascular, Boston Scientific and Biosensors. BH has received honoraria from Philips Volcano for consultancy.
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