Daily Meal Supplemented with Astaxanthin-Enriched Yolk Has Mitigative Effects against Hypertension in Spontaneously Hypertensive Rats.
Animals
Antihypertensive Agents
/ pharmacology
Aorta, Thoracic
/ drug effects
Blood Pressure
/ drug effects
Diet
Dietary Supplements
Endothelium, Vascular
/ drug effects
Hypertension
/ drug therapy
Male
Rats
Rats, Inbred SHR
Vasoconstriction
/ drug effects
Vasodilation
/ drug effects
Vasodilator Agents
/ pharmacology
Xanthophylls
/ pharmacology
astaxanthin-enriched egg yolk
hypertension
spontaneously hypertensive rat
Journal
Biological & pharmaceutical bulletin
ISSN: 1347-5215
Titre abrégé: Biol Pharm Bull
Pays: Japan
ID NLM: 9311984
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
25
9
2020
Statut:
ppublish
Résumé
The aim of this study was to investigate the effects of egg yolk powder enriched with astaxanthin (ASX-E) on blood pressure in spontaneously hypertensive rats (SHR) and to verify the benefits of ASX-E as a functional food. To investigate the antihypertensive effect, SHR were fed with an ASX-E mixed diet before hypertension development. Blood pressures were determined periodically during the study by the tail-cuff method. At the end of the study, animals were euthanized, and their thoracic aortas were collected to determine vascular conductance. The thoracic aorta tension was measured with a force displacement transducer. Concentration-dependent response relationships were determined by cumulative addition of 10
Identifiants
pubmed: 32115501
doi: 10.1248/bpb.b19-01013
doi:
Substances chimiques
Antihypertensive Agents
0
Vasodilator Agents
0
Xanthophylls
0
astaxanthine
8XPW32PR7I
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM