A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice.
CD8+ T cells
YFV-17D
chimeric flavivirus vaccine
live-attenuated vaccines
non-neutralizing antibodies
Journal
Emerging microbes & infections
ISSN: 2222-1751
Titre abrégé: Emerg Microbes Infect
Pays: United States
ID NLM: 101594885
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
20
3
2020
Statut:
epublish
Résumé
The recent Zika virus (ZIKV) epidemic in the Americas, followed by the yellow fever virus (YFV) outbreaks in Angola and Brazil highlight the urgent need for safe and efficient vaccines against the ZIKV as well as much greater production capacity for the YFV-17D vaccine. Given that the ZIKV and the YFV are largely prevalent in the same geographical areas, vaccines that would provide dual protection against both pathogens may obviously offer a significant benefit. We have recently engineered a chimeric vaccine candidate (YF-ZIKprM/E) by swapping the sequences encoding the YFV-17D surface glycoproteins prM/E by the corresponding sequences of the ZIKV. A single vaccine dose of YF-ZIKprM/E conferred complete protection against a lethal challenge with wild-type ZIKV strains. Surprisingly, this vaccine candidate also efficiently protected against lethal YFV challenge in various mouse models. We demonstrate that CD8
Identifiants
pubmed: 32116148
doi: 10.1080/22221751.2020.1730709
pmc: PMC7067203
doi:
Substances chimiques
Antibodies, Neutralizing
0
Yellow Fever Vaccine
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
520-533Références
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