Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells.
cell migration
fibrosis
pH homeostasis
pancreatic cancer
pancreatic stellate cells
piezo1
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
11
2019
accepted:
27
01
2020
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
3
3
2020
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an acidic and fibrotic stroma. The extracellular matrix (ECM) causing the fibrosis is primarily formed by pancreatic stellate cells (PSCs). The effects of the altered biomechanics and pH landscape in the pathogenesis of PDAC, however, are poorly understood. Mechanotransduction in cells has been linked to the function of mechanosensitive ion channels such as Piezo1. Here, we tested whether this channel plays crucial roles in transducing mechanical signals in the acidic PDAC microenvironment. We performed immunofluorescence, Ca
Identifiants
pubmed: 32116794
doi: 10.3389/fphys.2020.00089
pmc: PMC7033545
doi:
Types de publication
Journal Article
Langues
eng
Pagination
89Informations de copyright
Copyright © 2020 Kuntze, Goetsch, Fels, Najder, Unger, Wilhelmi, Sargin, Schimmelpfennig, Neumann, Schwab and Pethő.
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