Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation.
Foxp3
Foxp3 stability
Treg cells
autoimmunity
epigenetic regulation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
09
2019
accepted:
23
12
2019
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
20
11
2020
Statut:
epublish
Résumé
The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental insights into the understanding of the molecular determinants leading to generation and maintenance of T regulatory (Treg) cells, a cell population with a key immunoregulatory role. Work over the past few years has shown that fine-tuned transcriptional and epigenetic events are required to ensure stable expression of Foxp3 in Treg cells. The equilibrium between phenotypic plasticity and stability of Treg cells is controlled at the molecular level by networks of transcription factors that bind regulatory sequences, such as enhancers and promoters, to regulate Foxp3 expression. Recent reports have suggested that specific modifications of DNA and histones are required for the establishment of the chromatin structure in conventional CD4
Identifiants
pubmed: 32117202
doi: 10.3389/fimmu.2019.03136
pmc: PMC7008726
doi:
Substances chimiques
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3136Informations de copyright
Copyright © 2020 Colamatteo, Carbone, Bruzzaniti, Galgani, Fusco, Maniscalco, Di Rella, de Candia and De Rosa.
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