The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass.
Antibodies, Monoclonal
/ immunology
Antibody Affinity
Antineoplastic Agents, Immunological
/ immunology
Bacterial Proteins
/ metabolism
Cell Line
Complement C1q
/ immunology
GPI-Linked Proteins
/ genetics
Humans
Immunoglobulin Fab Fragments
/ immunology
Immunoglobulin Fc Fragments
/ immunology
Immunoglobulin G
/ immunology
Immunoglobulin Joining Region
/ metabolism
Killer Cells, Natural
/ metabolism
Matrix Metalloproteinase 12
/ metabolism
Proteolysis
Receptors, IgG
/ genetics
Transduction, Genetic
C1q
FcγRIIIA
MMP12
hinge region
ideS
immunoglobulin G subclass
proteolytic cleavage
therapeutic monoclonal antibodies
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
07
2019
accepted:
21
01
2020
entrez:
3
3
2020
pubmed:
3
3
2020
medline:
9
3
2021
Statut:
epublish
Résumé
The hinge region of immunoglobulin G (IgG) is involved in C1q and FcγRIIIA-expressing natural killer (NK) cell recruitment. Both heavy chains (HCs) of the hinge region can be cleaved sequentially by several proteases of the tumor/inflammatory/infectious microenvironment, including matrix metalloproteinase 12 (MMP12), or immunoglobulin-degrading enzyme from
Identifiants
pubmed: 32117299
doi: 10.3389/fimmu.2020.00168
pmc: PMC7026020
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antineoplastic Agents, Immunological
0
Bacterial Proteins
0
FCGR3A protein, human
0
FCGR3B protein, human
0
GPI-Linked Proteins
0
Immunoglobulin Fab Fragments
0
Immunoglobulin Fc Fragments
0
Immunoglobulin G
0
Immunoglobulin Joining Region
0
Mac-1-like protein, Streptococcus
0
Receptors, IgG
0
Complement C1q
80295-33-6
MMP12 protein, human
EC 3.4.24.65
Matrix Metalloproteinase 12
EC 3.4.24.65
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
168Informations de copyright
Copyright © 2020 Deveuve, Lajoie, Barrault and Thibault.
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