Surface Dependent Dual Recognition of a G-quadruplex DNA With Neomycin-Intercalator Conjugates.

DNA FID G-quadruplex Oxytricha Nova neomycin

Journal

Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988

Informations de publication

Date de publication:
2020
Historique:
received: 16 11 2019
accepted: 20 01 2020
entrez: 3 3 2020
pubmed: 3 3 2020
medline: 3 3 2020
Statut: epublish

Résumé

G-quadruplexes have been characterized as structures of vital importance in the cellular functioning of several life forms. They have subsequently been established to serve as a therapeutic target of several diseases including cancer, HIV, tuberculosis and malaria. In this paper, we report the binding of aminosugar-intercalator conjugates with a well-studied anti-parallel G-quadruplex derived from

Identifiants

pubmed: 32117884
doi: 10.3389/fchem.2020.00060
pmc: PMC7028757
doi:

Types de publication

Journal Article

Langues

eng

Pagination

60

Informations de copyright

Copyright © 2020 Ranjan, Andreasen, Arora, Xue and Arya.

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Auteurs

Nihar Ranjan (N)

Laboratory for Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC, United States.
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India.

Katrine F Andreasen (KF)

Laboratory for Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC, United States.

Yashaswina Arora (Y)

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, India.

Liang Xue (L)

Laboratory for Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC, United States.

Dev P Arya (DP)

Laboratory for Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC, United States.

Classifications MeSH