Structure-based discovery of potent and selective melatonin receptor agonists.


Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
02 03 2020
Historique:
received: 20 11 2019
accepted: 26 02 2020
pubmed: 3 3 2020
medline: 10 4 2021
entrez: 3 3 2020
Statut: epublish

Résumé

Melatonin receptors MT

Identifiants

pubmed: 32118583
doi: 10.7554/eLife.53779
pii: 53779
pmc: PMC7080406
doi:
pii:

Substances chimiques

Receptor, Melatonin, MT1 0
Receptor, Melatonin, MT2 0
Receptors, Melatonin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH112205
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK116195
Pays : United States

Informations de copyright

© 2020, Patel et al.

Déclaration de conflit d'intérêts

NP, XH, JG, LJ, BS, JM, YL, BR, VK No competing interests declared

Références

Chem Biol Drug Des. 2008 Jan;71(1):15-27
pubmed: 18069986
J Med Chem. 2018 Aug 09;61(15):6830-6845
pubmed: 29990431
Neuropharmacology. 2015 Apr;91:142-7
pubmed: 25534555
Curr Med Chem. 2012;19(21):3532-49
pubmed: 22680635
Nature. 2019 May;569(7755):289-292
pubmed: 31019305
J Comput Chem. 2012 Feb 15;33(5):561-72
pubmed: 22170280
Methods Mol Biol. 2012;857:189-205
pubmed: 22323222
Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61
pubmed: 12764576
J Med Chem. 2010 Feb 25;53(4):1799-809
pubmed: 20095623
Prog Neurobiol. 2011 Mar;93(3):350-84
pubmed: 21193011
Annu Rev Pharmacol Toxicol. 2016;56:361-83
pubmed: 26514204
Nucleic Acids Res. 2019 Jan 8;47(D1):D1102-D1109
pubmed: 30371825
Behav Brain Res. 2013 Apr 15;243:231-8
pubmed: 23333399
Sci Signal. 2018 Aug 28;11(545):
pubmed: 30154102
J Med Chem. 2010 Apr 8;53(7):2719-40
pubmed: 20131845
Neuron. 1994 Nov;13(5):1177-85
pubmed: 7946354
ACS Chem Neurosci. 2012 Mar 21;3(3):193-203
pubmed: 22860188
Eur J Pharmacol. 2015 Oct 5;764:424-432
pubmed: 26162699
Nucleic Acids Res. 2000 Jan 1;28(1):235-42
pubmed: 10592235
Br J Pharmacol. 2018 Aug;175(16):3263-3280
pubmed: 28707298
Nat Struct Mol Biol. 2019 Jul;26(7):535-544
pubmed: 31270468
Mol Pharmacol. 2013 Dec;84(6):794-807
pubmed: 24021214
Pharmacol Rev. 2019 Apr;71(2):267-315
pubmed: 30914442
Nature. 2019 Feb;566(7743):224-229
pubmed: 30728502
J Med Chem. 2014 Apr 24;57(8):3161-85
pubmed: 24228714
Nature. 2020 Mar;579(7800):609-614
pubmed: 32040955
Cell Tissue Res. 2002 Jul;309(1):127-37
pubmed: 12111543
Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169
pubmed: 27899622
Nat Rev Endocrinol. 2019 Feb;15(2):105-125
pubmed: 30531911
Nat Struct Mol Biol. 2015 May;22(5):362-9
pubmed: 25895059
N Engl J Med. 1997 Jan 16;336(3):186-95
pubmed: 8988899
J Med Chem. 2017 Apr 13;60(7):3070-3081
pubmed: 28339199
Expert Opin Ther Targets. 2016 Oct;20(10):1209-18
pubmed: 27082492
Endocrine. 2005 Jul;27(2):101-10
pubmed: 16217123
Expert Opin Drug Discov. 2018 Mar;13(3):241-248
pubmed: 29271261
Br J Pharmacol. 2016 Sep;173(18):2702-25
pubmed: 27314810
Science. 2017 Oct 20;358(6361):381-386
pubmed: 29051383
Nat Rev Drug Discov. 2014 Feb;13(2):105-21
pubmed: 24481311
Nature. 2019 May;569(7755):284-288
pubmed: 31019306
Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954
pubmed: 27899562
Sleep Med. 2006 Jan;7(1):17-24
pubmed: 16309958
J Chem Inf Model. 2012 Jan 23;52(1):1-6
pubmed: 22168315
J Mol Biol. 1994 Jan 21;235(3):983-1002
pubmed: 8289329
Drug Discov Today. 2004 May 15;9(10):430-1
pubmed: 15109945
J Chem Inf Model. 2015 Nov 23;55(11):2324-37
pubmed: 26479676
Neurosci Lett. 2009 Jun 26;457(2):93-6
pubmed: 19429170
Nat Rev Drug Discov. 2010 Aug;9(8):628-42
pubmed: 20577266
Neurol Res. 2017 Jun;39(6):559-565
pubmed: 28460563

Auteurs

Nilkanth Patel (N)

Department of Biological Sciences and Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, United States.

Xi Ping Huang (XP)

Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.
National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.

Jessica M Grandner (JM)

Department of Biological Sciences and Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, United States.

Linda C Johansson (LC)

Department of Biological Sciences and Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, United States.

Benjamin Stauch (B)

Department of Biological Sciences and Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, United States.

John D McCorvy (JD)

Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.
National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.

Yongfeng Liu (Y)

Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.
National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.

Bryan Roth (B)

Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.
National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.
Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, United States.

Vsevolod Katritch (V)

Department of Biological Sciences and Department of Chemistry, Bridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, United States.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH