Safety and Efficacy of a Novel Pneumatically Driven Extracorporeal Membrane Oxygenation Device.

Animals Extracorporeal Membrane Oxygenation / adverse effects Sheep Treatment Outcome

Journal

The Annals of thoracic surgery
ISSN: 1552-6259
Titre abrégé: Ann Thorac Surg
Pays: Netherlands
ID NLM: 15030100R

Informations de publication

Date de publication:
06 2020
Historique:
received: 10 10 2019
revised: 03 01 2020
accepted: 16 01 2020
pubmed: 3 3 2020
medline: 7 8 2020
entrez: 3 3 2020
Statut: ppublish

Résumé

Extracorporeal membrane oxygenation (ECMO) is rapidly becoming a mainstream technology for lung or heart/lung support. Current ECMO devices mostly consist of a power-driven centrifugal pump and a dedicated oxygenator. We studied the safety and efficacy of a novel, fully pneumatically driven ECMO device, which could be used in both venovenous or venoarterial mode in an animal model. Six healthy, awake sheep were treated with the Mobybox ECMO device (Hemovent, Aachen, Germany) over a 7-day period in a venovenous mode. Gas exchange, coagulation parameters, and safety were assessed. Using a blood flow rate of 2 L/min and a low sweep gas flow rate of 0.3 L/min, the PCO The pneumatically driven ECMO device provided excellent safety and physiologic efficacy in a 7-day sheep experiment without visible clotting, hemolysis, or sustained reductions in fibrinogen or platelets.

Sections du résumé

BACKGROUND
Extracorporeal membrane oxygenation (ECMO) is rapidly becoming a mainstream technology for lung or heart/lung support. Current ECMO devices mostly consist of a power-driven centrifugal pump and a dedicated oxygenator. We studied the safety and efficacy of a novel, fully pneumatically driven ECMO device, which could be used in both venovenous or venoarterial mode in an animal model.
METHODS
Six healthy, awake sheep were treated with the Mobybox ECMO device (Hemovent, Aachen, Germany) over a 7-day period in a venovenous mode. Gas exchange, coagulation parameters, and safety were assessed.
RESULTS
Using a blood flow rate of 2 L/min and a low sweep gas flow rate of 0.3 L/min, the PCO
CONCLUSIONS
The pneumatically driven ECMO device provided excellent safety and physiologic efficacy in a 7-day sheep experiment without visible clotting, hemolysis, or sustained reductions in fibrinogen or platelets.

Identifiants

DOI: 10.1016/j.athoracsur.2020.01.039 PMID: 32119858
pubmed: 32119858
pii: S0003-4975(20)30253-8
doi: 10.1016/j.athoracsur.2020.01.039
pii:
doi:

Types de publication

Evaluation Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1684-1691

Informations de copyright

Copyright © 2020 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Auteurs

Christian Karagiannidis (C)

Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS, Cologne, Germany; ECMO Centre, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University Hospital, Cologne, Germany. Electronic address: christian.karagiannidis@uni-wh.de.

Thilo Joost (T)

Hemovent, Aachen, Germany.

Stephan Strassmann (S)

Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS, Cologne, Germany; ECMO Centre, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University Hospital, Cologne, Germany.

Steffen Weber-Carstens (S)

Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany; Humboldt Universität zu Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany.

Alain Combes (A)

Service de Médecine Intensive-Réanimation, Institut de Cardiologie, Hôpital Pitié-Salpêtrière, Assistance Publique, Hopitaux de Paris, Paris, France.

Wolfram Windisch (W)

Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, ARDS, Cologne, Germany; ECMO Centre, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University Hospital, Cologne, Germany.

Daniel Brodie (D)

Center for Acute Respiratory Failure, Columbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, New York, New York.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Safety and Efficacy of a Novel Pneumatically...
questionsmedicales.fr › Procédures de chirurgie opératoire › Circulation extracorporelle › Oxygénation extracorporelle sur oxygénateur à membrane › Safety and Efficacy of a Novel Pneumatically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Safety and Efficacy of a Novel Pneumatically...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Safety and Efficacy of a Novel Pneumatically...