Non-oxidative band-3 clustering agents cause the externalization of phosphatidylserine on erythrocyte surfaces by a calcium-independent mechanism.
Acridine orange, ZnCl(2)
Band-3 aggregation
Erythrocytes
Phosphatidylserine externalization
Journal
Biochimica et biophysica acta. Biomembranes
ISSN: 1879-2642
Titre abrégé: Biochim Biophys Acta Biomembr
Pays: Netherlands
ID NLM: 101731713
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
29
10
2019
revised:
11
02
2020
accepted:
14
02
2020
pubmed:
3
3
2020
medline:
21
8
2020
entrez:
3
3
2020
Statut:
ppublish
Résumé
Aging of red blood cells (RBCs) is associated with alteration in a wide range of RBC features, occurring each on its own timescale. A number of these changes are interrelated and initiate a cascade of biochemical and structural transformations, including band-3 clustering and phosphatidylserine (PS) externalization. Using specific band-3 clustering agents (acridine orange (AO) and ZnCl
Identifiants
pubmed: 32119860
pii: S0005-2736(20)30056-0
doi: 10.1016/j.bbamem.2020.183231
pii:
doi:
Substances chimiques
Anion Exchange Protein 1, Erythrocyte
0
Annexin A5
0
Chlorides
0
Phosphatidylserines
0
SLC4A1 protein, human
0
Zinc Compounds
0
zinc chloride
86Q357L16B
Acridine Orange
F30N4O6XVV
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
183231Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.