Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials.
astaxanthin
carotenoids
episodic memory
inhibition
intervention
lutein
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
27 Feb 2020
27 Feb 2020
Historique:
received:
28
01
2020
revised:
22
02
2020
accepted:
24
02
2020
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Fruits and vegetables are generally rich in antioxidants such as carotenoids. Consumption of carotenoids is expected to have benefits on cognitive functions in humans. However, previous randomized controlled trials (RCT) using carotenoids have reported inconsistent results. Therefore, this systematic review (SR) aimed to summarize the effect of carotenoid intake on cognitive functions in humans. PubMed, Cochrane Library, Web of Science, and PsychoINFO were searched for research papers on carotenoid intake with the criteria that 1) oral carotenoid intake was evaluated using RCTs, 2) participants were healthy young, middle-aged, or older, and 3) cognitive functions were measured using RCTs. Five studies using lutein and two studies using astaxanthin met the inclusion criteria. Consumption of lutein and its isomer showed consistent results in selective improvement of visual episodic memory in young and middle-aged adults while inhibition was observed in middle-aged and older adults. One of the two included astaxanthin studies reported a significant improvement of verbal episodic memory performance in middle-aged adults. This SR showed that the 10 mg lutein per day for twelve months can lead to improvement of cognitive functions. Due to the small number of studies, it is difficult to conclude whether astaxanthin would have a positive effect on cognitive functions.
Sections du résumé
BACKGROUND
BACKGROUND
Fruits and vegetables are generally rich in antioxidants such as carotenoids. Consumption of carotenoids is expected to have benefits on cognitive functions in humans. However, previous randomized controlled trials (RCT) using carotenoids have reported inconsistent results. Therefore, this systematic review (SR) aimed to summarize the effect of carotenoid intake on cognitive functions in humans.
METHOD
METHODS
PubMed, Cochrane Library, Web of Science, and PsychoINFO were searched for research papers on carotenoid intake with the criteria that 1) oral carotenoid intake was evaluated using RCTs, 2) participants were healthy young, middle-aged, or older, and 3) cognitive functions were measured using RCTs.
RESULTS
RESULTS
Five studies using lutein and two studies using astaxanthin met the inclusion criteria. Consumption of lutein and its isomer showed consistent results in selective improvement of visual episodic memory in young and middle-aged adults while inhibition was observed in middle-aged and older adults. One of the two included astaxanthin studies reported a significant improvement of verbal episodic memory performance in middle-aged adults.
CONCLUSION
CONCLUSIONS
This SR showed that the 10 mg lutein per day for twelve months can lead to improvement of cognitive functions. Due to the small number of studies, it is difficult to conclude whether astaxanthin would have a positive effect on cognitive functions.
Identifiants
pubmed: 32120794
pii: nu12030617
doi: 10.3390/nu12030617
pmc: PMC7146131
pii:
doi:
Substances chimiques
Xanthophylls
0
astaxanthine
8XPW32PR7I
Lutein
X72A60C9MT
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : JSPS KAKENHI
ID : 19H01760
Organisme : JSPS KAKENHI
ID : 16KT0002
Organisme : Lion Corporation
ID : Lion Corporation
Déclaration de conflit d'intérêts
This study was a corroborative study between Institute of Development, Aging, and Cancer (IDAC), Tohoku University and Lion Corporation. supported by Lion Corporation. R.N and R.K received research grants from Lion Corporation. T.S., E.K, H.T., M.M., A.U., and M.A are full-time employees of Lion Corporation. The company policy was not involved in the study design, collection, analysis, interpretation of data, or writing of the manuscript. The authors declare that they have no other competing interests.
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