Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers.
high intensity focused ultrasound
histotripsy
intravascular ultrasound
microbubbles
sonothrombolysis
ultrasound contrast agents
ultrasound enhanced thrombolysis
Journal
Sensors (Basel, Switzerland)
ISSN: 1424-8220
Titre abrégé: Sensors (Basel)
Pays: Switzerland
ID NLM: 101204366
Informations de publication
Date de publication:
27 Feb 2020
27 Feb 2020
Historique:
received:
09
01
2020
revised:
21
02
2020
accepted:
24
02
2020
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
29
10
2020
Statut:
epublish
Résumé
One of the great advancements in the applications of piezoelectric materials is the application for therapeutic medical ultrasound for sonothrombolysis. Sonothrombolysis is a promising ultrasound based technique to treat blood clots compared to conventional thrombolytic treatments or mechanical thrombectomy. Recent clinical trials using transcranial Doppler ultrasound, microbubble mediated sonothrombolysis, and catheter directed sonothrombolysis have shown promise. However, these conventional sonothrombolysis techniques still pose clinical safety limitations, preventing their application for standard of care. Recent advances in sonothrombolysis techniques including targeted and drug loaded microbubbles, phase change nanodroplets, high intensity focused ultrasound, histotripsy, and improved intravascular transducers, address some of the limitations of conventional sonothrombolysis treatments. Here, we review the strengths and limitations of these latest pre-clincial advancements for sonothrombolysis and their potential to improve clinical blood clot treatments.
Identifiants
pubmed: 32120902
pii: s20051288
doi: 10.3390/s20051288
pmc: PMC7085655
pii:
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL141967
Pays : United States
Organisme : NIH HHS
ID : R01HL141967
Pays : United States
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