Total Synthesis of (-)-Anaferine: A Further Ramification in a Diversity-Oriented Approach.
2-piperidine ethanol
anaferine
bis-piperidine alkaloids
diversity-oriented synthesis
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Feb 2020
27 Feb 2020
Historique:
received:
10
02
2020
revised:
24
02
2020
accepted:
26
02
2020
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
14
1
2021
Statut:
epublish
Résumé
The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, employing commercially available 2-piperidine ethanol as a versatile precursor. Here, we report the exploration of another ramification of our DOS approach, that led us to the stereoselective total synthesis of (-)-anaferine, a bis-piperidine alkaloid present in
Identifiants
pubmed: 32120931
pii: molecules25051057
doi: 10.3390/molecules25051057
pmc: PMC7179133
pii:
doi:
Substances chimiques
Alkaloids
0
Piperidines
0
Plant Extracts
0
Ethanol
3K9958V90M
piperidine
67I85E138Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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