Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery.
antibacterial test
drug delivery
initiated chemical vapour deposition
poly(methyl methacrylate) (PMMA) copolymer
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
01 Mar 2020
01 Mar 2020
Historique:
received:
08
01
2020
revised:
22
02
2020
accepted:
25
02
2020
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
4
3
2020
Statut:
epublish
Résumé
A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.
Identifiants
pubmed: 32121608
pii: pharmaceutics12030213
doi: 10.3390/pharmaceutics12030213
pmc: PMC7150873
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Regione Puglia
ID : Apulian Industrial Plasma Laboratory
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PONa3_00369
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