Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 03 2020
02 03 2020
Historique:
received:
31
07
2019
accepted:
14
02
2020
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
13
11
2020
Statut:
epublish
Résumé
Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic steatohepatitis which is undergoing a dramatic evolution given the obesity progression worldwide, and has no treatment to date. Hepatic stellate cells (HSCs) play a key role in the fibrosis process, because in chronic liver damage, they transdifferentiate from a "quiescent" to an "activated" phenotype responsible for most the collagen deposition in liver tissue. Here, using a diet-induced liver fibrosis murine model (choline-deficient amino acid-defined, high fat diet), we characterized a specific population of HSCs organized as clusters presenting simultaneously hypertrophy of retinoid droplets, quiescent and activated HSC markers. We showed that hypertrophied HSCs co-localized with fibrosis areas in space and time. Importantly, we reported the existence of this phenotype and its association with collagen deposition in three other mouse fibrosis models, including CCl
Identifiants
pubmed: 32123215
doi: 10.1038/s41598-020-60615-0
pii: 10.1038/s41598-020-60615-0
pmc: PMC7052210
doi:
Substances chimiques
Dietary Fats
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3850Références
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