Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives.
Journal
ACS central science
ISSN: 2374-7943
Titre abrégé: ACS Cent Sci
Pays: United States
ID NLM: 101660035
Informations de publication
Date de publication:
26 Feb 2020
26 Feb 2020
Historique:
received:
07
11
2019
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
4
3
2020
Statut:
ppublish
Résumé
In this paper we report the synthesis of a library of phospho-amino acid analogues, via a novel single-step allyl-phosphoester protection/Pd-mediated deprotection strategy. These phosphoserine and phosphotyrosine analogues were then applied as additives to create adhesive calcium phosphate cements, allowing us to probe the chemical origins of the increased surface binding strength. We demonstrate the importance of multiple calcium binding motifs in mediating adhesion, as well as highlighting the crucial role played by substrate hydrophobicity and orientation in controlling binding strength.
Identifiants
pubmed: 32123740
doi: 10.1021/acscentsci.9b01149
pmc: PMC7047273
doi:
Types de publication
Journal Article
Langues
eng
Pagination
226-231Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare the following competing financial interest(s): M.P.-P., G.I., P.P., and H.E. declare partial ownership in a company that owns intellectual property related to PSer containing CPCs, GPBio LTD.
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