Drysdalin, an antagonist of nicotinic acetylcholine receptors highlights the importance of functional rather than structural conservation of amino acid residues.

Cys‐loop receptor recognition nicotinic acetylcholine receptor nonhomologous mutation protein‐protein interaction snake venom neurotoxin

Journal

FASEB bioAdvances
ISSN: 2573-9832
Titre abrégé: FASEB Bioadv
Pays: United States
ID NLM: 101733210

Informations de publication

Date de publication:
Feb 2019
Historique:
received: 30 07 2018
revised: 30 07 2018
accepted: 19 10 2018
entrez: 4 3 2020
pubmed: 10 1 2019
medline: 10 1 2019
Statut: epublish

Résumé

Snake venom neurotoxins are potent antagonists of nicotinic acetylcholine receptors (nAChRs). Here, we describe a novel member of class 3c long-chain neurotoxin drysdalin from the venom of

Identifiants

pubmed: 32123825
doi: 10.1096/fba.1027
pii: FBA21027
pmc: PMC6996315
doi:

Types de publication

Journal Article

Langues

eng

Pagination

115-131

Informations de copyright

© 2018 The Authors.

Déclaration de conflit d'intérêts

5The authors declare that they have no conflict of interest.

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Auteurs

Ritu Chandna (R)

Protein Science Laboratory, Department of Biological Sciences National University of Singapore Singapore.

Han-Shen Tae (HS)

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong Wollongong NSW Australia.

Victoria A L Seymour (VAL)

Burnet Institute Melbourne VIC Australia.

Shifali Chathrath (S)

Protein Science Laboratory, Department of Biological Sciences National University of Singapore Singapore.

David J Adams (DJ)

Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong Wollongong NSW Australia.

R Manjunatha Kini (RM)

Protein Science Laboratory, Department of Biological Sciences National University of Singapore Singapore.

Classifications MeSH