Losing maleness: Somatic Y chromosome loss at every stage of a man's life.
Turner syndrome
Y chromosome
infertility
karyotype
somatic mosaicism
Journal
FASEB bioAdvances
ISSN: 2573-9832
Titre abrégé: FASEB Bioadv
Pays: United States
ID NLM: 101733210
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
16
01
2019
revised:
25
02
2019
accepted:
12
03
2019
entrez:
4
3
2020
pubmed:
4
3
2020
medline:
4
3
2020
Statut:
epublish
Résumé
Mosaic loss of Y chromosome (LOY) is assumed to be among the most common acquired genetic variations in elderly people. Recent studies have linked aging-related mosaic LOY to the risk of Alzheimer's disease, cancer, and early death. Here, we propose that mosaic LOY can present in men at any age. Mosaic LOY appears to be associated with disorders of sex development and Turner syndrome at birth, short stature from childhood, and spermatogenic failure at reproductive age, in addition to shortened survival after 60 years of age.
Identifiants
pubmed: 32123838
doi: 10.1096/fba.2019-00006
pii: FBA21046
pmc: PMC6996334
doi:
Types de publication
Journal Article
Langues
eng
Pagination
350-352Informations de copyright
© 2019 The Authors.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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