Chemical Metabolism of Xenobiotics by Gut Microbiota.
Xenobiotics
bioactivity
bioavailability
drug metabolism
gut microbiota
pollutants
toxicity.
Journal
Current drug metabolism
ISSN: 1875-5453
Titre abrégé: Curr Drug Metab
Pays: Netherlands
ID NLM: 100960533
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
12
2019
revised:
05
01
2020
accepted:
12
02
2020
pubmed:
4
3
2020
medline:
11
5
2021
entrez:
4
3
2020
Statut:
ppublish
Résumé
Among the gut microbiota's newly explored roles in human biology is the ability to modify the chemical structures of foreign compounds (xenobiotics). A growing body of evidence has now provided sufficient acumen on the role of the gut microbiota on xenobiotic metabolism, which could have an intense impact on the therapy for various diseases in the future. Gut microbial xenobiotic metabolites have altered bioavailability, bioactivity and toxicity and can intervene with the actions of human xenobiotic-metabolizing enzymes to affect the destiny of other ingested molecules. These modifications are diverse and could lead to physiologically important consequences. In the current manuscript we aim to review the data currently available on how the gut microbiota directly modifies drugs, dietary compounds, chemicals, pollutants, pesticides and herbal supplements.
Identifiants
pubmed: 32124693
pii: CDM-EPUB-104965
doi: 10.2174/1389200221666200303113830
doi:
Substances chimiques
Environmental Pollutants
0
Pharmaceutical Preparations
0
Xenobiotics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
260-269Informations de copyright
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