Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Animals
Cysteine Endopeptidases
/ metabolism
Cysteine Proteinase Inhibitors
/ chemical synthesis
Drug Design
Enzyme Assays
Humans
Kinetics
Mice
Molecular Docking Simulation
Myoblasts, Cardiac
/ drug effects
Peptidomimetics
/ chemical synthesis
Protein Binding
Protozoan Proteins
/ antagonists & inhibitors
Pyridines
/ chemical synthesis
Pyrimidines
/ chemical synthesis
Trypanocidal Agents
/ chemical synthesis
Trypanosoma brucei brucei
/ drug effects
Trypanosoma cruzi
/ drug effects
Vinyl Compounds
/ chemical synthesis
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
26 03 2020
26 03 2020
Historique:
pubmed:
4
3
2020
medline:
15
9
2020
entrez:
4
3
2020
Statut:
ppublish
Résumé
Cruzain, an essential cysteine protease of the parasitic protozoan,
Identifiants
pubmed: 32125159
doi: 10.1021/acs.jmedchem.9b02078
pmc: PMC7261474
mid: NIHMS1581809
doi:
Substances chimiques
Cysteine Proteinase Inhibitors
0
Peptidomimetics
0
Protozoan Proteins
0
Pyridines
0
Pyrimidines
0
Trypanocidal Agents
0
Vinyl Compounds
0
Cysteine Endopeptidases
EC 3.4.22.-
cruzipain
EC 3.4.22.51
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3298-3316Subventions
Organisme : NIAID NIH HHS
ID : R21 AI127634
Pays : United States
Références
J Med Chem. 2019 Oct 24;62(20):9026-9044
pubmed: 31539239
J Exp Med. 1998 Aug 17;188(4):725-34
pubmed: 9705954
Antimicrob Agents Chemother. 2005 Dec;49(12):5160-1
pubmed: 16304193
Antimicrob Agents Chemother. 2014;58(2):1167-78
pubmed: 24323474
Infect Dis Clin North Am. 2012 Jun;26(2):275-91
pubmed: 22632639
Mol Biochem Parasitol. 2001 Nov;118(1):61-73
pubmed: 11704274
J Am Chem Soc. 2014 Sep 10;136(36):12624-30
pubmed: 25153195
Handb Clin Neurol. 2013;114:169-81
pubmed: 23829907
Methods Enzymol. 1995;249:240-83
pubmed: 7791614
PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0005850
pubmed: 30138309
J Biol Chem. 2008 Oct 24;283(43):28934-43
pubmed: 18701454
J Med Chem. 2004 Mar 25;47(7):1750-9
pubmed: 15027866
J Biol Chem. 2006 May 5;281(18):12824-32
pubmed: 16520377
Nat Rev Drug Discov. 2006 Sep;5(9):730-9
pubmed: 16888652
Drug Discov Today. 2018 Mar;23(3):727-735
pubmed: 29337202
Nature. 2010 Jun 24;465(7301):S6-7
pubmed: 20571554
PLoS Pathog. 2011 Sep;7(9):e1002139
pubmed: 21909255
Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820
pubmed: 28800383
J Med Chem. 2019 Dec 12;62(23):10497-10525
pubmed: 31361135
Medicina (B Aires). 1999;59 Suppl 2:171-5
pubmed: 10668260
Biol Chem. 2015 Aug;396(8):867-82
pubmed: 25872877
Pharmacol Ther. 2015 Nov;155:105-16
pubmed: 26299995
J Med Chem. 2006 Oct 19;49(21):6177-96
pubmed: 17034125
Endocr Rev. 2017 Aug 1;38(4):325-350
pubmed: 28651365
Nat Chem Biol. 2015 Jul;11(7):525-31
pubmed: 26006010
Biochemistry. 2012 Dec 18;51(50):10087-98
pubmed: 23181936
Am J Trop Med Hyg. 2016 Dec 7;95(6):1225-1227
pubmed: 27402515
Chem Commun (Camb). 2012 Jan 21;48(6):835-7
pubmed: 22124229
Mol Biochem Parasitol. 1993 Mar;58(1):17-24
pubmed: 8459830
Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:263-9
pubmed: 19753483
Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9
pubmed: 17698625
Biochemistry. 1990 Aug 21;29(33):7608-17
pubmed: 2271521
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Adv Enzymol Relat Areas Mol Biol. 1988;61:201-301
pubmed: 3281418
PLoS Med. 2008 Feb;5(2):e55
pubmed: 18303943
Int J Antimicrob Agents. 2003 Aug;22(2):155-9
pubmed: 12927956
J Mol Biol. 1995 Mar 24;247(2):251-9
pubmed: 7707373
Int J Parasitol. 2012 May 1;42(5):481-8
pubmed: 22549023
J Pharm Sci. 2012 Mar;101(3):888-94
pubmed: 22161779
Eur J Biochem. 2001 May;268(9):2733-41
pubmed: 11322895
J Med Chem. 2010 Jan 14;53(1):52-60
pubmed: 19908842
J Biol Chem. 1992 Apr 15;267(11):7411-20
pubmed: 1559982
Lancet Neurol. 2013 Feb;12(2):186-94
pubmed: 23260189
Biochemistry. 2012 Sep 25;51(38):7551-68
pubmed: 22928782
PLoS Negl Trop Dis. 2010 Sep 14;4(9):
pubmed: 20856868
J Biol Chem. 2009 Sep 18;284(38):25697-703
pubmed: 19620707
Biochemistry. 2018 Jun 5;57(22):3176-3190
pubmed: 29336553
Heart Fail Rev. 2012 Jan;17(1):45-64
pubmed: 21165698
J Chem Inf Model. 2014 Jul 28;54(7):1932-40
pubmed: 24916536
ACS Med Chem Lett. 2015 Dec 15;7(1):77-82
pubmed: 26819670